Results 251 to 260 of about 139,185 (274)

Abstract 4440: Genetic knockdown of the E3 ubiquitin ligase Itch increases pancreatic cell line sensitivity to cancer therapeutics: A comparison between different gene editing techniques

Cancer Research, 2019
Abstract Introduction: E3 ligases are responsible for tagging ubiquitin onto substrates to either activate, relocate or target the substrate for degradation via the proteasome. Previous studies have shown that genetic knockdown of the E3 ubiquitin ligase Itch caused an increase in sensitivity to gemcitabine in pancreatic cancer models ...
Oliver J. Read, David J. Harrison, Paul A. Reynolds   +2 more
openaire   +1 more source

Development of lentiviral vector mediated gene transfer techniques as tools to overexpress/knockdown P2X4 receptors in vitro

2015
The current study focused on the development of recombinant lentiviral (rLV) mediated gene transfer techniques that would aid in testing the hypothesis that the purinergic P2X4 receptors (P2X4Rs) play an important role in behavioral effects of alcohol.
openaire   +1 more source

Understanding Gene FunctionAntisense Knockdown versus Homologous Recombination Knockout Techniques

1997
G FRASER, C WAHLESTEDT
openaire   +1 more source

Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression

Molecular Therapy - Nucleic Acids, 2022
Francisco José Ortega, Aina Lluch, Aleix Gavaldà-Navarro   +2 more
exaly  

KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors

Nucleic Acids Research, 2020
Fengcui Qian, Chun-Quan Li
exaly  

A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown

CheM, 2019
Michelle H Teplensky, Chetan Poudel, Colin Hockings   +2 more
exaly  

Near-Infrared-Light-Based Nano-Platform Boosts Endosomal Escape and Controls Gene Knockdown in Vivo

ACS Nano, 2014
Muthu kumara gnanasammandhan Jayakumar, Akshaya Bansal, Kai Huang   +2 more
exaly  

Construction of a Gene Knockdown System Based on Catalytically Inactive (“Dead”) Cas9 (dCas9) in Staphylococcus aureus

Applied and Environmental Microbiology, 2017
Changlong Zhao, Baolin Sun
exaly  

Dysregulation of gene expression in ABCC6 knockdown HepG2 cells

Cellular and Molecular Biology Letters, 2014
Maria Francesca Armentano, Monica Carmosino, Faustino Bisaccia   +2 more
exaly  

Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown

Molecular Therapy - Nucleic Acids, 2019
Francis Rousset, Patrick Salmon, Renier Myburgh   +2 more
exaly