Results 21 to 30 of about 137,996 (276)

Ku80 gene knockdown by the CRISPR/Cas9 technique affects the biological functions of human thyroid carcinoma cells

Oncology Reports, 2019
In the present study, to evaluate the role of Ku80 in thyroid carcinoma (TC), 86 thyroid tissue samples from patients with a spectrum of thyroid disorders were examined for protein levels of Ku80, nuclear factor‑κB (NF‑κB) and RET/TC by immunohistochemistry.
Fan, Yali, Li, Jianying, Wei, Wei, Fang, Hangrong, Duan, Ying, Li, Namiao, Zhang, Yingying, Yu, Jun, Wang, Juanhong   +8 more
openaire   +3 more sources

Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus [PDF]

, 1996
The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of DNA methylation signals leading to gene silencing. We investigated their binding specificity at the constitutively methylated region of a CpG island containing the ...
Auriol, Emilie, Billard, Lise-Marie, Magdinier, Frédérique, Dante, Robert   +3 more
core   +2 more sources

Essentiality of Plasmodium falciparum plasmepsin V.

PLoS ONE, 2018
The malaria parasite replicates within erythrocytes. The pathogenesis of clinical malaria is in large part due to the capacity of the parasite to remodel its host cell.
Nonlawat Boonyalai, Christine R Collins, Fiona Hackett, Chrislaine Withers-Martinez, Michael J Blackman   +4 more
doaj   +1 more source

Mammalian RNAi: a practical guide

BioTechniques, 2005
Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for the functional annotation of the Cae-norhabditis elegans and Drosophila melanogaster genomes.
Peter Sandy, Andrea Ventura, Tyler Jacks
doaj   +1 more source

Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells. [PDF]

PLoS ONE, 2014
Gene therapy continues to grow as an important area of research, primarily because of its potential in the treatment of disease. One significant area where there is a need for better understanding is in improving the efficiency of oligonucleotide ...
Meesbah Jiwaji, Mairi E Sandison, Julien Reboud, Ross Stevenson, Rónán Daly, Gráinne Barkess, Karen Faulds, Walter Kolch, Duncan Graham, Mark A Girolami, Jonathan M Cooper, Andrew R Pitt   +11 more
doaj   +1 more source

Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity [PDF]

, 2011
The design of synthetic gene networks requires an extensive genetic toolbox to control the activities and levels of protein components to achieve desired cellular functions.
Alper, Alper, Alper, Anderson, Andrew H. Babiskin, Babiskin, Babiskin, Basu, Beisel, Callura, Caponigro, Carrier, Chanfreau, Chanfreau, Chao, Christina D. Smolke, Danin-Kreiselman, Elela, Ellis, Elowitz, Gardner, Ge, Gietz, Hawkins, Hawkins, Isaacs, Jensen, Jin, Jones, Keiler, Lamontagne, Lamontagne, Lamontagne, Lamontagne, Lamontagne, Lamontagne, Larose, Lautz, Lavoie, Lee, Louis, Lutz, Mateus, Misra, Nevoigt, Ng, Nguyen, Ostergaard, Paradise, Pfleger, Ro, Salis, Sambrook, Szczebara, Vasudevan, Veen, Win, Wu, Wu, Zhou, Zhou, Zhu, Zhu   +62 more
core   +3 more sources

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

Recurrent deletions of ULK4 in schizophrenia : a gene crucial for neuritogenesis and neuronal motility [PDF]

, 2013
Peer reviewedPublisher ...
Blackwood, Douglas H, Gao, Guo-Dong, Guan, Zhen-Long, He, Guang, He, Lin, Hunter, Irene, Lang, Bing, Li, Wei-Dong, Liu, Min, Martin-Granados, Christina, McCaig, Colin D, Pu, Jin, Reilly, Thomas J, Shen, Sanbing, Shi, Yong-Yong, St Clair, David, Stefansson, Hreinn   +16 more
core   +1 more source

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis [PDF]

, 2020
Strategies for controlled delivery of therapeutic siRNA into living cells are in high demand as endosomal escape remains the most prominent bottleneck at the intracellular level.
Barriga, Gerardo Garcia-Diaz, Braeckmans, Kevin, Brans, Toon, De Keulenaer, Sarah, De Rycke, Riet, De Smedt, Stefaan, De Vos, Winnok H., Fraire, Juan, Houthaeve, Gaëlle, Liu, Jing, Mestdagh, Pieter, Raemdonck, Koen, Raes, Laurens, Stremersch, Stephan, Van Nieuwerburgh, Filip, Vandesompele, Jo, Vermeulen, Lotte   +16 more
core   +2 more sources

Comparing artificial neural networks, general linear models and support vector machines in building predictive models for small interfering RNAs. [PDF]

PLoS ONE, 2009
BackgroundExogenous short interfering RNAs (siRNAs) induce a gene knockdown effect in cells by interacting with naturally occurring RNA processing machinery. However not all siRNAs induce this effect equally.
Kyle A McQuisten, Andrew S Peek
doaj   +1 more source