Results 211 to 220 of about 27,029,195 (311)

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Candidate promoter-associated factors of <i>BrAGPS1</i> identified by yeast one-hybrid screening in Chinese cabbage during <i>Plasmodiophora brassicae</i> infection. [PDF]

Front Plant Sci
Wang X, Ye T, Wu Y, Li Y, Yan Q, Jiang J, Liang Y, Pang W.   +7 more
europepmc   +1 more source

Spectral Reconstruction Using Broadband Inkjet‐Printed Optical Filters

Advanced Optical Materials, EarlyView.
A proof‐of‐concept for a reconstructive spectrometer based on inkjet‐printed interferometric optical filters is demonstrated. Through adaptive encoding and robust post‐processing algorithms, spectral reconstruction is achieved over a 400 nm visible bandwidth at a fraction of the cost and complexity of typical encoders while maintaining high optical ...
Leonardo Baini, Qihao Jin, Qiaoshuang Zhang, Guillaume Gomard, Uli Lemmer, Paolo Bartolini, Andrea Taschin, Diederik S. Wiersma, Renato Torre, Alice Boschetti   +9 more
wiley   +1 more source

Mapping structural constraints and adaptive potential in a capsule-degrading phage tailspike protein. [PDF]

Sci Adv
Evert S, Huss P, Kuppa Baskaran DK, Anantharaman K, Raman S.   +4 more
europepmc   +1 more source

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Deciphering transcriptome complexity via long-read sequencing. [PDF]

Imeta
Xu C, Li J, Yin C, Li K, Wang T, Gao S, Yu Y, Chang C, Wang Y, Tong G, Gong L, Hu W, Chai G, Han Y, Qin Q, Jin S, Zou X, Li B, Zhang T, Conesa A, Wang Y, Wang D.   +21 more
europepmc   +1 more source

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Machine-Learning-Assisted Pathway Optimization in Large Combinatorial Design Spaces: A p-Coumaric Acid Case Study. [PDF]

ACS Synth Biol
van Lent P, van der Hoek R, Moreno Paz S, Kooi I, Jonkers M, Zwartjens P, Schmitz J, Abeel T.   +7 more
europepmc   +1 more source