Results 111 to 120 of about 2,855,271 (302)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]

, 2005
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia, Braig, Claudia, Engel, Jutta, Hirt, Bernhard, Knipper, Marlies, Knirsch, Martina, Köpschall, Iris, Langer, Patricia, Müller, Marcus, Münkner, Stefan, Pfaff, Imke, Pfister, Markus, Rohbock, Karin, Ruth, Peter, Rüsch, Alfons, Rüttiger, Lukas, Sausbier, Matthias, Winter, Harald, Zimmermann, Ulrike   +18 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Recurrent DCC gene losses during bird evolution

Scientific Reports, 2017
AbstractDuring development, midline crossing by axons brings into play highly conserved families of receptors and ligands. The interaction between the secreted ligand Netrin-1 and its receptor Deleted in Colorectal Carcinoma (DCC) is thought to control midline attraction of crossing axons.
Friocourt, François, Lafont, Anne-Gaëlle, Kress, Clémence, Pain, Bertrand, Manceau, Marie, Dufour, Sylvie, Chédotal, Alain   +6 more
openaire   +5 more sources

Complete mitochondrial genome of Syzygium samarangense reveals genomic recombination, gene transfer, and RNA editing events

Frontiers in Plant Science
Wax apple (Syzygium samarangense) is a commercial fruit that belongs to one of the most species-rich tree genera in the world. We report here the first complete S. samarangense mitogenome obtained using a hybrid assembly strategy.
Guilong Lu, Guilong Lu, Qing Li
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Gene Loss DB: A curated database for gene loss in vertebrate species.

Molecular databases are essential resources for both experimental and computational biologists. The rapid increase in high-quality genome assemblies has led to a surge in publications describing secondary gene loss events associated with lineage-specific adaptations across diverse vertebrate groups.
Goncalo Espregueira Themudo, Raquel Ruivo, Raul Valente, Nadia Artilheiro, Diogo Oliveira, Ines Amorim, Bernardo Pinto, L. Filipe C. Castro, Sergio Fernandes, Monica Lopes-Marques   +9 more
openaire   +1 more source

Squamate reptiles may have compensated for the lack of γδTCR with a duplication of the TRB locus

Frontiers in Immunology
Squamate reptiles are amongst the most successful terrestrial vertebrate lineages, with over 10,000 species across a broad range of ecosystems. Despite their success, squamates are also amongst the least studied lineages immunologically.
Jordan M. Sampson, Kimberly A. Morrissey, Kieran J. Mikolajova, Kourtney M. Zimmerly, Neil J. Gemmell, Michael G. Gardner, Terry Bertozzi, Terry Bertozzi, Robert D. Miller   +8 more
doaj   +1 more source