Results 151 to 160 of about 1,645,919 (262)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A Deep Dive into the Globin Superfamily of Sharks, Skates, and Rays: Contrasting Patterns of Gene Loss and Retention Relative to Bony Vertebrates. [PDF]

Genome Biol Evol
Walt HK, Hinton JA, Kuraku S, Opazo JC, Storz JF, Hoffmann FG.   +5 more
europepmc   +1 more source

Comparative-genomic analysis reveals dynamic NLR gene loss and gain across Apiaceae species. [PDF]

Front Genet, 2023
Liang X, Dong J.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota. [PDF]

Natl Sci Rev
Rao YZ, Li YX, Li ZW, Qu YN, Hedlund BP, Williams TA, Qi YL, Xie QJ, Yang HL, Zhang YQ, Jiang HC, Palmer M, Shi M, Shu WS, Hua ZS, Li WJ.   +15 more
europepmc   +1 more source

Species Tree Estimation and the Impact of Gene Loss Following Whole-Genome Duplication. [PDF]

Syst Biol, 2022
Xiong H, Wang D, Shao C, Yang X, Yang J, Ma T, Davis CC, Liu L, Xi Z.   +8 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Recursive Ectopic Gene Conversion Leads to Elevated DNA Mutation, Gene Loss, and Novel Gene Formation in Aspergillus. [PDF]

Microorganisms
Wang R, Liu W, Liu T, Wang T, Chen H, Qi H, Wang J, Lan M, Wang X.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Symbiosis with and mimicry of corals were facilitated by immune gene loss and body remodeling in the pygmy seahorse. [PDF]

Proc Natl Acad Sci U S A
Qu M, Zhang Y, Woltering J, Liu Y, Liu Z, Wan S, Jiang H, Yu H, Chen Z, Wang X, Zhang Z, Qin G, Schneider R, Meyer A, Lin Q.   +14 more
europepmc   +1 more source