Results 161 to 170 of about 1,645,919 (262)

Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation. [PDF]

Proc Biol Sci, 2022
Divín D, Goméz Samblas M, Kuttiyarthu Veetil N, Voukali E, Świderská Z, Krajzingrová T, Těšický M, Beneš V, Elleder D, Bartoš O, Vinkler M.   +10 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer. [PDF]

Mol Syst Biol
Venkatesh A, Quinn N, Upadhya SR, De Kegel B, Bolado Carrancio A, Lefeivre T, Dennler O, Wynne K, von Kriegsheim A, Ryan CJ.   +9 more
europepmc   +1 more source

Community diversity is associated with intra-species genetic diversity and gene loss in the human gut microbiome. [PDF]

Elife, 2023
Madi N, Chen D, Wolff R, Shapiro BJ, Garud NR.   +4 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Gene loss in Antarctic icefish: evolutionary adaptations mimicking Fanconi Anemia? [PDF]

BMC Genomics
Shin SC, Kim S, Kim HW, Lee JH, Kim JH.
europepmc   +1 more source

Gene loss and co-option of toll-like receptors facilitate paternal immunological adaptation in the brood pouch of pregnant male seahorses. [PDF]

Front Immunol, 2023
Zhang B, Xiao W, Qin G, Chen Z, Qiu L, Wang X, Lin Q.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Comparative plastomes of five <i>Psittacanthus</i> species: genome organization, structural features, and patterns of pseudogenization and gene loss. [PDF]

AoB Plants
Morales-Saldaña S, Barraza-Ochoa AI, Villafán E, Vásquez-Aguilar AA, Ramírez-Barahona S, Ibarra-Laclette E, Ornelas JF.   +6 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source