Results 181 to 190 of about 6,611,862 (305)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Memory loss, Alzheimer's disease, and dementia : a practical guide for clinicians /

Now presented in full color, this updated edition of Memory Loss, Alzheimer's Disease, and Dementia is designed as a practical guide for clinicians that delivers the latest treatment approaches and research findings for dementia and related illnesses ...
Preceeded by:Budson, Andrew E.Memory loss.2011., Budson, Andrew E.,author., Solomon, Paul R.,author.   +2 more
core  

Comparative chloroplast genome analysis of four <i>Trigonella</i> species: structural rearrangements, gene loss, and phylogenetic relationships. [PDF]

Front Plant Sci
Nagar R, Patial V, Mohanpuria P, Ms N, Choudhary S.   +4 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss

Alveolar bone loss in elderly populations is highly prevalent and increases the risk of tooth loss, gum disease susceptibility, and facial deformity. Unfortunately, there are very limited treatment options available.
Xie, Jun, Chen, Dong, Gao, Guangping, Shim, Jae-Hyuck, Lin, Chujiao, John, Aijaz Ahmad, Ma, Hong, Yang, Yeon-Suk, Chen, Zhihao   +8 more
core   +1 more source

PseudoChecker2 and PseudoViz: automation and visualization of gene loss in the Genome Era. [PDF]

Bioinform Adv
Resende-Pinto R, Ruivo R, Stiller J, Fonseca R, Castro LFC.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

<i>TP53</i>-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition. [PDF]

Sci Adv
Spinella JF, Chagraoui J, Moison C, Boivin I, Carpentier GR, Mayotte N, Béliveau F, Lavallée VP, Hébert J, Sauvageau G.   +9 more
europepmc   +1 more source

Cold-Driven Hemoglobin Evolution in Antarctic Notothenioid Fishes Prior to Hemoglobin Gene Loss in White-Blooded Icefishes. [PDF]

Mol Biol Evol, 2023
Desvignes T, Bista I, Herrera K, Landes A, Postlethwait JH.   +4 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source