Results 201 to 210 of about 13,329,719 (303)

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Symbiosis with and mimicry of corals were facilitated by immune gene loss and body remodeling in the pygmy seahorse. [PDF]

Proc Natl Acad Sci U S A
Qu M, Zhang Y, Woltering J, Liu Y, Liu Z, Wan S, Jiang H, Yu H, Chen Z, Wang X, Zhang Z, Qin G, Schneider R, Meyer A, Lin Q.   +14 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer. [PDF]

Mol Syst Biol
Venkatesh A, Quinn N, Upadhya SR, De Kegel B, Bolado Carrancio A, Lefeivre T, Dennler O, Wynne K, von Kriegsheim A, Ryan CJ.   +9 more
europepmc   +1 more source

Community diversity is associated with intra-species genetic diversity and gene loss in the human gut microbiome. [PDF]

Elife, 2023
Madi N, Chen D, Wolff R, Shapiro BJ, Garud NR.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Gene loss in Antarctic icefish: evolutionary adaptations mimicking Fanconi Anemia? [PDF]

BMC Genomics
Shin SC, Kim S, Kim HW, Lee JH, Kim JH.
europepmc   +1 more source

Gene loss and co-option of toll-like receptors facilitate paternal immunological adaptation in the brood pouch of pregnant male seahorses. [PDF]

Front Immunol, 2023
Zhang B, Xiao W, Qin G, Chen Z, Qiu L, Wang X, Lin Q.   +6 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Comparative plastomes of five <i>Psittacanthus</i> species: genome organization, structural features, and patterns of pseudogenization and gene loss. [PDF]

AoB Plants
Morales-Saldaña S, Barraza-Ochoa AI, Villafán E, Vásquez-Aguilar AA, Ramírez-Barahona S, Ibarra-Laclette E, Ornelas JF.   +6 more
europepmc   +1 more source