Results 201 to 210 of about 6,611,862 (305)

Illuminating the mystery of thylacine extinction: a role for relaxed selection and gene loss. [PDF]

Proc Biol Sci
Salve BG, Vijay N.
europepmc   +1 more source

Gene Loss may have Shaped the Cnidarian and Bilaterian Hox and ParaHox Complement. [PDF]

Genome Biol Evol, 2023
Steinworth BM, Martindale MQ, Ryan JF.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota. [PDF]

Natl Sci Rev
Rao YZ, Li YX, Li ZW, Qu YN, Hedlund BP, Williams TA, Qi YL, Xie QJ, Yang HL, Zhang YQ, Jiang HC, Palmer M, Shi M, Shu WS, Hua ZS, Li WJ.   +15 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Envelope for Miss Gene E. Smith, Beaver Dam, Wisconsin, 1866

An item in the George Woodard and Gene Smith letters ...
Smith, Gene E.
core  

A Deep Dive into the Globin Superfamily of Sharks, Skates, and Rays: Contrasting Patterns of Gene Loss and Retention Relative to Bony Vertebrates. [PDF]

Genome Biol Evol
Walt HK, Hinton JA, Kuraku S, Opazo JC, Storz JF, Hoffmann FG.   +5 more
europepmc   +1 more source

Comparative-genomic analysis reveals dynamic NLR gene loss and gain across Apiaceae species. [PDF]

Front Genet, 2023
Liang X, Dong J.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Recursive Ectopic Gene Conversion Leads to Elevated DNA Mutation, Gene Loss, and Novel Gene Formation in Aspergillus. [PDF]

Microorganisms
Wang R, Liu W, Liu T, Wang T, Chen H, Qi H, Wang J, Lan M, Wang X.   +8 more
europepmc   +1 more source