Results 271 to 280 of about 6,611,862 (305)

Loss of heterozygosity of the PTCH gene in ameloblastoma

Human Pathology, 2012
Ameloblastoma is a locally aggressive benign neoplasm derived from odontogenic epithelium, with high recurrence rates. Alterations in the Sonic Hedgehog signaling pathway, including PTCH gene mutations, have been associated with the pathogenesis of some odontogenic tumors.
Lucyana Conceição, Farias, Carolina Cavalieri, Gomes, João Artur Ricieri, Brito, Clarice Ferreira, Galvão, Marina Gonçalves, Diniz, Wagner Henriques, de Castro, Vanessa de Fátima, Bernardes, Luiz Armando, De Marco, Ricardo Santiago, Gomez   +8 more
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Gene Therapy for Sensorineural Hearing Loss

Ear & Hearing, 2015
Gene therapy is a promising treatment modality that is being explored for several inherited disorders. Multiple human gene therapy clinical trials are currently ongoing, but few are directed at hearing loss. Hearing loss is one of the most prevalent sensory disabilities in the world, and genetics play an important role in the pathophysiology of hearing
Wade W, Chien, Elyssa L, Monzack, Devin S, McDougald, Lisa L, Cunningham   +3 more
openaire   +2 more sources

Gene therapy for hereditary hearing loss

Hearing Research
Gene therapy is a technique by which exogenous genetic material is introduced into target cells to treat or prevent diseases caused by genetic mutations. Hearing loss is the most common sensory disorder. Genetic factors contribute to approximately 50 % of all cases of profound hearing loss, and more than 150 independent genes have been reported as ...
Liping Zhao, Jingpu Yang, Zeming Fu
exaly   +3 more sources

Gene loss, thermogenesis, and the origin of birds

Annals of the New York Academy of Sciences, 2013
Compared to related taxa, birds have exceptionally enlarged and diversified skeletal muscles, features that are closely associated with skeletal diversification and are commonly explained by a diversity of avian ecological niches and locomotion types. The thermogenic muscle hypothesis (TMH) for the origin of birds proposes that such muscle hyperplasia ...
Stuart A, Newman, Nadezhda V, Mezentseva, Alexander V, Badyaev   +2 more
openaire   +2 more sources

Prospects for Gene Therapy in Hearing Loss

Journal of Basic and Clinical Physiology and Pharmacology, 2003
Deafness is the most common form of sensory impairment in humans. Depending on the age of onset, hearing impairment can affect oral language acquisition, cognitive development and psychosocial development. Here, we cover the latest advances in gene therapy for alleviating or preventing hearing loss.
Karen B, Avraham, Yehoash, Raphael
openaire   +2 more sources

Limitations of Pseudogenes in Identifying Gene Losses

2008
The loss of previously established genes has been proposed as a major force in evolutionary change. While the sequencing of many new species offers the opportunity to identify cases of gene loss, the best method to do this with is unclear. A number of methods to identify gene losses rely on the presence of a pseudogene for each loss.
James C. Costello, Mira V. Han, Matthew W. Hahn   +2 more
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Microbial Genes in the Human Genome: Lateral Transfer or Gene Loss?

Science, 2001
The human genome was analyzed for evidence that genes had been laterally transferred into the genome from prokaryotic organisms. Protein sequence comparisons of the proteomes of human, fruit fly, nematode worm, yeast, mustard weed, eukaryotic parasites, and all completed prokaryote genomes were performed, and all genes shared between human and each of ...
S L, Salzberg, O, White, J, Peterson, J A, Eisen   +3 more
openaire   +2 more sources

Evolution of mitochondrial gene content: gene loss and transfer to the nucleus

Molecular Phylogenetics and Evolution, 2003
Mitochondrial gene content is highly variable across extant eukaryotes. The number of mitochondrial protein genes varies from 3 to 67, while tRNA gene content varies from 0 to 27. Moreover, these numbers exclude the many diverse lineages of non-respiring eukaryotes that lack a mitochondrial genome yet still contain a mitochondrion, albeit one often ...
Keith L, Adams, Jeffrey D, Palmer
openaire   +2 more sources

Gene Therapy to Treat Profound Hearing Loss

New England Journal of Medicine
Abstract: The authors describe the scientific foundations of a study of gene therapy for hearing loss caused by damaging variants in the gene OTOF.
Paul Van de Heyning, Vincent Van Rompaey
openaire   +3 more sources

Gene Losses in the Human Genome

Science, 2012
A comprehensive survey of the human genome reveals variations that disrupt protein-coding genes.
openaire   +1 more source