Results 21 to 30 of about 1,645,919 (262)
Gene therapy for hearing loss [PDF]
Human Molecular Genetics, 2019 Abstract Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying etiologies include a broad spectrum of genetic and environmental factors that can lead to hearing loss that is congenital or late onset, stable or progressive, drug related, noise induced, age related, traumatic or post-infectious. Habilitation
Ryotaro Omichi +3 more
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Gene Loss and Evolution of the Plastome [PDF]
Genes, 2019 Abstract Chloroplasts are unique organelles within the plant cells and are responsible for sustaining life forms on the earth due to their ability to conduct photosynthesis. Multiple functional genes within the chloroplast are responsible for a variety of metabolic processes that occur in the chloroplast.
Tapan Kumar Mohanta +5 more
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Extensive loss of Wnt genes in Tardigrada [PDF]
BMC Ecology and Evolution, 2021 AbstractBackgroundWnt genes code for ligands that activate signaling pathways during development in Metazoa. Through the canonical Wnt (cWnt) signaling pathway, these genes regulate important processes in bilaterian development, such as establishing the anteroposterior axis and posterior growth. In Arthropoda, Wnt ligands also regulate segment polarity,
Chavarria, Raul A. +5 more
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The loss of taste genes in cetaceans [PDF]
BMC Evolutionary Biology, 2014 Five basic taste modalities, sour, sweet, bitter, salt and umami, can be distinguished by humans and are fundamental for physical and ecological adaptations in mammals. Molecular genetic studies of the receptor genes for these tastes have been conducted in terrestrial mammals; however, little is known about the evolution and adaptation of these genes ...
Zhu, Kangli +6 more
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Phylogenetic reconstruction with gene rearrangements and gene losses [PDF]
2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2010 Reconstructing phylogenies from gene-order data has become very attractive in the research of evolution these years. So far, most methods can only treat genomes with equal gene contents with each gene appearing exactly once in each genome. In this paper, we propose a new distance measurement for genomes with inversions and insertions/deletions that ...
Yiwei Zhang, Fei Hu, Jijun Tang
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The impact of local genomic properties on the evolutionary fate of genes
eLife, 2023 Functionally indispensable genes are likely to be retained and otherwise to be lost during evolution. This evolutionary fate of a gene can also be affected by factors independent of gene dispensability, including the mutability of genomic positions, but ...
Yuichiro Hara, Shigehiro Kuraku
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Gene Loss and Movement in the Maize Genome [PDF]
Genome Research, 2004 Maize (Zea mays L. ssp. mays), one of the most important agricultural crops in the world, originated by hybridization of two closely related progenitors. To investigate the fate of its genes after tetraploidization, we analyzed the sequence of five duplicated regions from different chromosomal locations.
Lai J. +10 more
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Frontiers in Genetics, 2020 We take advantage of synteny blocks, the analytical construct enabled at the evolutionary moment of speciation or polyploidization, to follow the independent loss of duplicate genes in two sister species or the loss through fractionation of syntenic ...
Zhe Yu +3 more
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Frontiers in Plant Science, 2022 MADS-box is an important transcription factor family that is involved in the regulation of various stages of plant growth and development, especially flowering regulation and flower development.
Kunyu Duan +8 more
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The life cycle of Drosophila orphan genes
eLife, 2014 Orphans are genes restricted to a single phylogenetic lineage and emerge at high rates. While this predicts an accumulation of genes, the gene number has remained remarkably constant through evolution. This paradox has not yet been resolved.
Nicola Palmieri +2 more
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