Results 41 to 50 of about 119,093 (246)

Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies

BMC Genomics, 2020
Background Based on an initial collecting of database sequences from the gap junction protein gene family (also called connexin genes) in a few teleosts, the naming of these sequences appeared variable. The reasons could be (i) that the structure in this
Svein-Ole Mikalsen, Marni Tausen, Sunnvør í Kongsstovu   +2 more
doaj   +1 more source

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

Journal of Lipid Research, 2010
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage ...
Alan R. Kimmel, Dawn L. Brasaemle, Monica McAndrews-Hill, Carole Sztalryd, Constantine Londos   +4 more
doaj   +1 more source

Proposal of a new nomenclature for introns in protein-coding genes in fungal mitogenomes

IMA Fungus, 2019
Fungal mitochondrial genes are often invaded by group I or II introns, which represent an ideal marker for understanding fungal evolution. A standard nomenclature of mitochondrial introns is needed to avoid confusion when comparing different fungal ...
Shu Zhang, Yong-Jie Zhang
doaj   +1 more source

RGST - Rat Gene Symbol Tracker, a database for defining official rat gene symbols

BMC Genomics, 2008
Background The names of genes are central in describing their function and relationship. However, gene symbols are often a subject of controversy. In addition, the discovery of mammalian genes is now so rapid that a proper use of gene symbol nomenclature
Ståhl Fredrik, Petersen Greta
doaj   +1 more source

Finding one's way in proteomics: a protein species nomenclature

Chemistry Central Journal, 2009
Our knowledge of proteins has greatly improved in recent years, driven by new technologies in the fields of molecular biology and proteome research. It has become clear that from a single gene not only one single gene product but many different ones ...
Holzhütter Hermann-Georg, Apweiler Rolf, Schlüter Hartmut, Jungblut Peter R   +3 more
doaj   +1 more source

Use of gene sequences as type for naming prokaryotes: Recommendations of the international committee on the taxonomy of chlamydiae

New Microbes and New Infections, 2023
The International Committee on Systematics of Prokaryotes (ICSP) discussed and rejected in 2020 a proposal to modify the International Code of Nomenclature of Prokaryotes to allow the use of gene sequences as type for naming prokaryotes.
Gilbert Greub, Trestan Pillonel, Patrik M. Bavoil, Nicole Borel, Lee Ann Campbell, Deborah Dean, Scott Hefty, Matthias Horn, Servaas A. Morré, Scot P. Ouellette, Yvonne Pannekoek, Mirja Puolakkainen, Peter Timms, Raphael Valdivia, Daisy Vanrompay   +14 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Correction to: Atypical hyperglycemia presentation suggests considering a diagnostic of other types of diabetes: first reported GCK-MODY in Perú

Clinical Diabetes and Endocrinology, 2020
It was highlighted that the original article [1] contained an error regarding the nomenclature in the gene described.
Juan Carlos Lizarzaburu-Robles, Juan Carlos Gomez-de-la-Torre, María del Carmen Castro-Mujica, Flor Vento, Sofia Villanes, Elizabeth Salsavilca, Chris Guerin   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source