Results 51 to 60 of about 123,439 (272)
Finding one's way in proteomics: a protein species nomenclature
Chemistry Central Journal, 2009 Our knowledge of proteins has greatly improved in recent years, driven by new technologies in the fields of molecular biology and proteome research. It has become clear that from a single gene not only one single gene product but many different ones ...
Holzhütter Hermann-Georg +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Clinical Diabetes and Endocrinology, 2020 It was highlighted that the original article [1] contained an error regarding the nomenclature in the gene described.
Juan Carlos Lizarzaburu-Robles +6 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Gene and transgenics nomenclature for the laboratory axolotl – Ambystoma mexicanum
, 2021 The laboratory axolotl (Ambystoma mexicanum) is widely used in biological research. Recent advancements in genetic and molecular toolkits are greatly accelerating the work using axolotl, especially in the area of tissue regeneration.
Nowoshilow, Sergej +9 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Guidelines for Human Gene Nomenclature
Genomics, 2002 Guidelines for human gene nomenclature were first pub-lished in 1979 [1], when the Human Gene NomenclatureCommittee was first given the authority to approve andimplement human gene names and symbols. Updates of theseguidelines were published in 1987 [2], 1995 [3], and 1997 [4].With the recent publications of the complete human genomesequence there is ...
Hester M, Wain +5 more
openaire +2 more sources
Gene name ambiguity of eukaryotic nomenclatures [PDF]
Bioinformatics, 2004 AbstractMotivation: With more and more scientific literature published online, the effective management and reuse of this knowledge has become problematic. Natural language processing (NLP) may be a potential solution by extracting, structuring and organizing biomedical information in online literature in a timely manner.
Lifeng Chen +2 more
openaire +2 more sources