Results 111 to 120 of about 7,457,987 (378)
Ontologies for the study of neurological disease [PDF]
, 2012 We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of ...
Cox, Alexander P. +7 more
core
Inferring gene ontologies from pairwise similarity data. [PDF]
, 2014 MotivationWhile the manually curated Gene Ontology (GO) is widely used, inferring a GO directly from -omics data is a compelling new problem. Recognizing that ontologies are a directed acyclic graph (DAG) of terms and hierarchical relations, algorithms ...
Bafna, Vineet +4 more
core +2 more sources
bioRxiv, 2018 Identifying disease genes from a vast amount of genetic data is one of the most challenging tasks in the post-genomic era. Also, complex diseases present highly heterogeneous genotype, which difficult biological marker identification.
M. Asif +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Mining functional gene modules by multi-view NMF of phenome-genome association
BMC GenomicsBackground Mining functional gene modules from genomic data is an important step to detect gene members of pathways or other relations such as protein-protein interactions.
Xu Jin +8 more
doaj +1 more source
Biomedical ontologies and their development, management, and applications in and beyond China
Journal of Bio-X Research, 2019 . Since the boom of biomedical big data studies, various big data processing technologies have been developed rapidly. As an important form of knowledge representation, ontology has become an important means for the utilization and integration of ...
Hongjie Pan +6 more
doaj +1 more source
Automatically linking MEDLINE abstracts to the Gene Ontology [PDF]
, 2003 Much has been written recently about the need for effective tools and methods for mining the wealth of information present in biomedical literature (Mack and Hehenberger, 2002; Blagosklonny and Pardee, 2001; Rindflesch et al., 2002)—the activity of ...
Cleary, John G., Smith, Tony C.
core +1 more source
The Plant Ontology facilitates comparisons of plant development stages across species [PDF]
, 2019 The Plant Ontology (PO) is a community resource consisting of standardized terms, definitions, and logical relations describing plant structures and development stages, augmented by a large database of annotations from genomic and phenomic studies.
Cooper, Laurel +7 more
core +2 more sources
Gene ontology enrichment analysis of congenital diaphragmatic hernia-associated genes
Pediatric Research, 2018 Congenital diaphragmatic hernia (CDH) is a commonly occurring major congenital anomaly with a profound impact on neonatal mortality. The etiology of CDH is poorly understood and is complicated by multiple clinical presentations, reflecting the location ...
Timothy R. A. Dalmer, Robin D. Clugston
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source