Results 81 to 90 of about 426,507 (329)
Evaluation of high-throughput functional categorization of human disease genes
BMC Bioinformatics, 2007 Background Biological data that are well-organized by an ontology, such as Gene Ontology, enables high-throughput availability of the semantic web. It can also be used to facilitate high throughput classification of biomedical information.
Li Jianrong +4 more
doaj +1 more source
Extending gene ontology with gene association networks [PDF]
Bioinformatics, 2015 Abstract Motivation: Gene ontology (GO) is a widely used resource to describe the attributes for gene products. However, automatic GO maintenance remains to be difficult because of the complex logical reasoning and the need of biological knowledge that are not explicitly represented in the GO.
Jiajie Peng +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Comparing Relational and Ontological Triple Stores in Healthcare Domain
Entropy, 2017 Today’s technological improvements have made ubiquitous healthcare systems that converge into smart healthcare applications in order to solve patients’ problems, to communicate effectively with patients, and to improve healthcare service quality.
Ozgu Can +3 more
doaj +1 more source
, 2009 Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions ...
Alan Ruttenberg +20 more
core +3 more sources
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Discovering gene annotations in biomedical text databases
BMC Bioinformatics, 2008 Background Genes and gene products are frequently annotated with Gene Ontology concepts based on the evidence provided in genomics articles. Manually locating and curating information about a genomic entity from the biomedical literature requires vast ...
Ozsoyoglu Gultekin, Cakmak Ali
doaj +1 more source
Aligning the top-level of SNOMED-CT with Basic Formal Ontology [PDF]
, 2008 Effective translational research requires automated analysis of large datasets collected by multiple researchers working at multiple locations. Reliable, machine interpretation of-—and reasoning with—-large datasets assembled at different ...
William Hogan
core +2 more sources
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Mining functional gene modules by multi-view NMF of phenome-genome association
BMC GenomicsBackground Mining functional gene modules from genomic data is an important step to detect gene members of pathways or other relations such as protein-protein interactions.
Xu Jin +8 more
doaj +1 more source