Results 71 to 80 of about 396,263 (266)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
STUDY OF THE TOMATO GENE POOL OF VIR WORLD COLLECTION IN THE OPEN GROUND IN MOSCOW REGION
Овощи России, 2015 The results of study of 62 tomato accessions from the world collection of VIR in the open ground are presented. The promising samples from different groups of ripeness were selected for several valuable agronomic characters.
V. I. Kozak, V. E. Udaeva
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
NEW FLORISTIC FINDINGS ON THE NORTH-WEST PAMIR-ALAY (UZBEKISTAN)
Turczaninowia, 2015 This article is focused on six species newley recorded for the flora of Nuratau and Malguzar mountains (North-West Pamir-Alay), which are revealed during the field studies and examination of TASH herbarium specimens in 2011–2012.
N. Yu. Beshko, D. E. Azimova
doaj
FEATURES OF GROWING AND STORAGE OF SEED COLLECTION OF THE GENE POOL OF VEGETABLE CROPS.
Овощи России, 2015 The features of cultivation and storage of seed collections of the gene pool of vegetable crops have been studied. Elements to improve growing techniques of seeds for dispatch for long term storage are offered. The optimal conditions for storage of
O. N. Shabetya
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
GENE POOL FOR BREEDING MONOGERM TABLE BEET
Труды по прикладной ботанике, генетике и селекции, 2018 Results of studying the collection accessions of table beet with different levels of monogermity are presented. Inheritance of this character in the progeny and also its connection with other traits and properties are shown.
V. I. Burenin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source