Results 61 to 70 of about 168,249 (259)

The problem of conservation of gene pools of domesticated animals

Вавиловский журнал генетики и селекции, 2017
In the paper the principles and methods of gene pools preservation of domestic animals breeds are explored. Currently 17 % of world species are under threat of extinction.
Yu. A. Stolpovskiy, I. A. Zakharov-Gezekhus   +1 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Stability of the effect of silencing fibronectin type III domain-protein 1 (FN3D1) gene on Anopheles arabiensis reared under different breeding site conditions

Parasites & Vectors, 2020
Background Malaria vector mosquitoes acquire midgut microbiota primarily from their habitat. The homeostasis of these microbial communities plays an essential role in the mosquito longevity, the most essential factor in the mosquito vectorial capacity ...
Serkadis Debalke, Tibebu Habtewold, George K. Christophides, Luc Duchateau   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Frequency of Uterine Malformation among Women in a Restricted Gene Pool Community : A retrospective cross-sectional study in La Crete, Canada

Sultan Qaboos University Medical Journal, 2007
Objective: This random retrospective cross-sectional study was done to determine the incidence of uterine malformation in 4 groups of women desiring to conceive during their reproductive years, all of them living in La Crete, a community in Northern ...
Saad Ramzi Ismail
doaj  

Emergence of Japanese encephalitis virus genotype V in the Republic of Korea

Virology Journal, 2011
Background Japanese encephalitis virus (JEV) genotype V reemerged in Asia (China) in 2009 after a 57-year hiatus from the continent, thereby emphasizing a need to increase regional surveillance efforts.
Grieco John, Lee Won-Ja, Klein Terry A, Kengluecha Ampornpan, Tippayachai Bousaraporn, Kim Heung-Chul, Takhampunya Ratree, Evans Brian P   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of wild accessions of g. barbadense l. from Peru and Brazil via microsatellite markers

Bioscience Journal, 2016
Peru and Brazil are recognized as primary and secondary centers of G. barbadense L., which is a species that stands out for producing long cotton fiber. However, since its introduction in Brazil, G. barbadense L.
Josiane Isabela da Silva Rodrigues, Luiz Paulo de Carvalho, Franscisco José Correia Farias   +2 more
doaj   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Decrypting the Mitochondrial Gene Pool of Modern Panamanians

PLoS ONE, 2012
El istmo de Panamá, la estrecha franja de tierra que conecta las masas terrestres del norte y sur de América, era un corredor obligatorio para los paleoindios cuando se mudaron a América del Sur. La evidencia arqueológica sugiere un vínculo ininterrumpido entre los nativos modernos y sus antepasados paleoindios en algunas áreas de Panamá, incluso si ...
Ugo A. Perego, Hovirag Lancioni, Maribel Tribaldos, Norman Angerhofer, Jayne E. Ekins, Anna Olivieri, Scott R. Woodward, Juan Miguel Pascale, Richard G. Cooke, Jorge Motta, Alessandro Achilli   +10 more
openaire   +6 more sources