Results 71 to 80 of about 319,651 (293)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Decrypting the Java gene pool [PDF]
Proceedings of the 6th international symposium on Memory management, 2007 Pretenuring long-lived and immortal objects into infrequently or never collected regions reduces garbage collection costs significantly. However, extant approaches either require computationally expensive, application-specific, off-line profiling, or consider only allocation sites common to all programs, i.e.
Sebastien Marion +2 more
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Genetics and Molecular Biology, 2007 An understanding of the relationship of geographically different soybean gene pools, based on selectively neutral DNA markers would be useful for the selection of divergent parental cultivars for use in breeding.
Naoki Yamanaka +8 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Estimating the impact of the Mongol expansion upon the gene pool of Tuvans
Вавиловский журнал генетики и селекции, 2018 With a view to trace the Mongol expansion in Tuvinian gene pool we studied two largest Tuvinian clans – those in which, according to data of humanities, one could expect the highest Central Asian ancestry, connected with the Mongol expansion.
L. D. Damba +11 more
doaj +1 more source
Nature Communications, 2023 Common bean has two distinct domestication centers in Mesoamerica and in the Andes. The authors show that the Andean is the first gene pool successfully introduced in Europe and identify signature of pervasive introgression among gene pools and of ...
Elisa Bellucci +28 more
doaj +1 more source
Journal of Dairy Science, 1984 The trend in the artificial insemination industry in recent years has been to sample larger numbers of sons sired by the most popular bulls. This trend has caused concern in the dairy industry regarding inbreeding and the gene pool. The known detrimental effects of inbreeding on economically important traits are one reason for this concern, and these ...
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 2012 At first Rickettsia conorii was implicated as the causative agent of spotted fever in Uruguay diagnosed by serological assays. Later Rickettsia parkeri was detected in human-biting Amblyomma triste ticks using molecular tests.
José M. Venzal +9 more
doaj +1 more source