Results 81 to 90 of about 319,651 (293)

SARS-CoV-2 detection in multi-sample pools in a real pandemic scenario: A screening strategy of choice for active surveillance.

PLoS ONE, 2022
BackgroundThe current COVID-19 pandemic has overloaded the diagnostic capacity of laboratories by the gold standard method rRT-PCR. This disease has a high spread rate and almost a quarter of infected individuals never develop symptoms. In this scenario,
Andrés Marcos Castellaro, Pablo Velez, Guillermo Giaj Merlera, Juan Rondan Dueñas, Felix Condat, Jesica Gallardo, Aylen Makhoul, Camila Cinalli, Lorenzo Rosales Cavaglieri, Guadalupe Di Cola, Paola Sicilia, Laura López, Facultad de Ciencias Químicas UNC Group, José Luis Bocco, María Gabriela Barbás, Diego Hernán Cardozo, María Belén Pisano, Viviana Ré, Andrea Belaus, Gonzalo Castro   +19 more
doaj   +1 more source

Lentiviral vectors with amplified beta cell-specific gene expression. [PDF]

, 2009
An important goal of gene therapy is to be able to deliver genes, so that they express in a pattern that recapitulates the expression of an endogenous cellular gene.
Crooks, GM, Ge, S, Hardee, C, Hollis, RP, Kohn, DB, Pais, E, Shaw, KL, Skelton, D   +7 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The problem of conservation of gene pools of domesticated animals

Вавиловский журнал генетики и селекции, 2017
In the paper the principles and methods of gene pools preservation of domestic animals breeds are explored. Currently 17 % of world species are under threat of extinction.
Yu. A. Stolpovskiy, I. A. Zakharov-Gezekhus   +1 more
doaj   +1 more source

Stability of the effect of silencing fibronectin type III domain-protein 1 (FN3D1) gene on Anopheles arabiensis reared under different breeding site conditions

Parasites & Vectors, 2020
Background Malaria vector mosquitoes acquire midgut microbiota primarily from their habitat. The homeostasis of these microbial communities plays an essential role in the mosquito longevity, the most essential factor in the mosquito vectorial capacity ...
Serkadis Debalke, Tibebu Habtewold, George K. Christophides, Luc Duchateau   +3 more
doaj   +1 more source

Sequencing the transcriptome of R570 to explore the complexity of the sugarcane genome [W1019] [PDF]

, 2020
Sugarcane is a crop of unequivocal importance which can meet requirements for food, feed fiber and fuel. This crop, with a large wealth of genetic resources and a rich breeding history, has only a very nascent genomic history with a monoploid genome ...
Aitken, Karen S., Barry, Kerrie W., Botha, Frikkie, D'Hont, Angélique, Furtado, Agnelo, Grimwood, Jane, Healey, Adam, Henry, Robert, Karabian Masouleh, Ardy, Kumar Pazhany, Adhini Sudhindra, O'Keeffe, Angela, Perlo, Virginie, Schmutz, Jeremy   +12 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Emergence of Japanese encephalitis virus genotype V in the Republic of Korea

Virology Journal, 2011
Background Japanese encephalitis virus (JEV) genotype V reemerged in Asia (China) in 2009 after a 57-year hiatus from the continent, thereby emphasizing a need to increase regional surveillance efforts.
Grieco John, Lee Won-Ja, Klein Terry A, Kengluecha Ampornpan, Tippayachai Bousaraporn, Kim Heung-Chul, Takhampunya Ratree, Evans Brian P   +7 more
doaj   +1 more source

Dynamic Pooling for the Combination of Forecasts Generated Using Multi Level Learning [PDF]

, 2007
In this paper we provide experimental results and extensions to our previous theoretical findings concerning the combination of forecasts that have been diversified by three different methods: with parameters learned at different data aggregation ...
Gabrys, Bogdan, Riedel, Silvia
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source