Results 31 to 40 of about 2,805,831 (274)
Comparative Analysis of Normalization Methods for Network Propagation
Frontiers in Genetics, 2019 Network propagation is a central tool in biological research. While a number of variants and normalizations have been proposed for this method, each has its own shortcomings and no large scale assessment of those variants is available.
Hadas Biran, Martin Kupiec, Roded Sharan
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Disease Gene Prioritization Using Network and Feature [PDF]
Journal of Computational Biology, 2015 Identifying high-confidence candidate genes that are causative for disease phenotypes, from the large lists of variations produced by high-throughput genomics, can be both time-consuming and costly. The development of novel computational approaches, utilizing existing biological knowledge for the prioritization of such candidate genes, can improve the ...
Bingqing Xie +6 more
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The developed algorithm to calculate Gene-Disease Prioritization Score (GDPS).
, 2023 The developed algorithm to calculate Gene-Disease Prioritization Score (GDPS).
Yael Shvili (14626677) +2 more
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Frontiers in Genetics, 2018 Dissecting the genetic susceptibility to intellectual disability (ID) based on de novo mutations (DNMs) will aid our understanding of the neurobiological and genetic basis of ID. In this study, we identify 63 high-confidence ID genes with q-values < 0.
Zhenwei Liu +7 more
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G3: Genes, Genomes, Genetics, 2019 Genetic mapping is a primary tool of genetics in model organisms; however, many quantitative trait loci (QTL) contain tens or hundreds of positional candidate genes. Prioritizing these genes for validation is often ad hoc and biased by previous findings.
Anna L. Tyler +8 more
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Prioritizing disease candidate genes by a gene interconnectedness-based approach [PDF]
BMC Genomics, 2011 Abstract Background Genome-wide disease-gene finding approaches may sometimes provide us with a long list of candidate genes. Since using pure experimental approaches to verify all candidates could be expensive, a number of network-based methods have been developed to prioritize candidates.
Hsu Chia-Lang +3 more
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Benchmarker: An Unbiased, Association-Data-Driven Strategy to Evaluate Gene Prioritization Algorithms. [PDF]
Am J Hum Genet, 2019 Fine RS +4 more
europepmc +2 more sources
Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis [PDF]
International Journal of Molecular Sciences, 2016 Ectopic pregnancy is a very dangerous complication of pregnancy, affecting 1%–2% of all reported pregnancies. Due to ethical constraints on human biopsies and the lack of suitable animal models, there has been little success in identifying functionally important genes in the pathogenesis of ectopic pregnancy. In the present study, we developed a random
Liu, Ji-Long, Zhao, Miao
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Integrating computational biology and forward genetics in Drosophila. [PDF]
PLoS Genetics, 2009 Genetic screens are powerful methods for the discovery of gene-phenotype associations. However, a systems biology approach to genetics must leverage the massive amount of "omics" data to enhance the power and speed of functional gene discovery in vivo ...
Stein Aerts +8 more
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HGG Advances, 2023 Summary: We introduce a user-friendly tool for risk gene, cell type, and drug prioritization for complex traits: GCDPipe. It uses gene-level GWAS-derived data and gene expression data to train a model for the identification of disease risk genes and ...
Daria Pinakhina +3 more
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