Results 21 to 30 of about 2,805,831 (274)
GWAS to Identify Novel QTNs for WSCs Accumulation in Wheat Peduncle Under Different Water Regimes
Frontiers in Plant Science, 2022 Water-soluble carbohydrates (WSCs) play a vital role in water stress avoidance and buffering wheat grain yield. However, the genetic architecture of stem WSCs’ accumulation is partially understood, and few candidate genes are known.
Arpit Gaur +15 more
doaj +1 more source
WINNER: A network biology tool for biomolecular characterization and prioritization
Frontiers in Big Data, 2022 Background and contributionIn network biology, molecular functions can be characterized by network-based inference, or “guilt-by-associations.” PageRank-like tools have been applied in the study of biomolecular interaction networks to obtain further the ...
Thanh Nguyen +6 more
doaj +1 more source
Prioritization of nasal polyp-associated genes by integrating GWAS and eQTL summary data
Frontiers in Genetics, 2023 Background: Nasal polyps (NP) are benign inflammatory growths of nasal and paranasal sinus mucosa that can substantially impair patients’ quality of life by various symptoms such as nasal obstruction, insomnia, and anosmia.
Masahiro Yoshikawa +4 more
doaj +1 more source
Frontiers in Genetics, 2021 Celiac disease (CeD) is a complex T cell-mediated enteropathy induced by gluten. Although genome-wide association studies have identified numerous genomic regions associated with CeD, it is difficult to accurately pinpoint which genes in these loci are ...
Adriaan van der Graaf +29 more
doaj +1 more source
MGM Journal of Medical Sciences, 2023 Background: The present study aimed to identify biomarker genes associated with disease progression from an early and advanced stage to metastatic oral squamous cell carcinoma (OSCC) and to explore their regulatory mechanism. Materials and Methods: Three
Jyotsna Choubey +2 more
doaj +1 more source
System-Level Analysis of Alzheimer’s Disease Prioritizes Candidate Genes for Neurodegeneration
Frontiers in Genetics, 2021 Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder. Since the advent of the genome-wide association study (GWAS) we have come to understand much about the genes involved in AD heritability and pathophysiology.
Jeffrey L. Brabec +4 more
doaj +1 more source
PRODIGY: personalized prioritization of driver genes [PDF]
Bioinformatics, 2018 Abstract Motivation Evolution of cancer is driven by few somatic mutations that disrupt cellular processes, causing abnormal proliferation and tumor development, whereas most somatic mutations have no impact on progression.
Gal Dinstag, Ron Shamir
openaire +2 more sources
An unbiased evaluation of gene prioritization tools [PDF]
Bioinformatics, 2012 Abstract Motivation: Gene prioritization aims at identifying the most promising candidate genes among a large pool of candidates—so as to maximize the yield and biological relevance of further downstream validation experiments and functional studies.
Daniela Börnigen +6 more
openaire +3 more sources
Genetic Foundations of Nellore Traits: A Gene Prioritization and Functional Analyses of Genome-Wide Association Study Results. [PDF]
Genes (Basel)Ogunbawo AR +3 more
europepmc +2 more sources
FUN-L: gene prioritization for RNAi screens [PDF]
Bioinformatics, 2015 Abstract Motivation: Most biological processes remain only partially characterized with many components still to be identified. Given that a whole genome can usually not be tested in a functional assay, identifying the genes most likely to be of interest is of critical importance to avoid wasting resources.
Jonathan G. Lees +10 more
openaire +3 more sources