Results 1 to 10 of about 2,805,831 (274)
Text Mining in Cancer Gene and Pathway Prioritization [PDF]
Cancer Informatics, 2014 Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental verifications will succeed. A multitude
Yuan Luo +2 more
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A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases [PDF]
Journal of Integrative Bioinformatics, 2019 Modern high-throughput experiments provide us with numerous potential associations between genes and diseases. Experimental validation of all the discovered associations, let alone all the possible interactions between them, is time-consuming and ...
Zolotareva Olga, Kleine Maren
doaj +4 more sources
PRIORI-T: A tool for rare disease gene prioritization using MEDLINE. [PDF]
PLoS ONE, 2020 IntroductionPhenotype-driven rare disease gene prioritization relies on high quality curated resources containing disease, gene and phenotype annotations.
Aditya Rao +5 more
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Scuba: scalable kernel-based gene prioritization [PDF]
BMC Bioinformatics, 2018 Background The uncovering of genes linked to human diseases is a pressing challenge in molecular biology and precision medicine. This task is often hindered by the large number of candidate genes and by the heterogeneity of the available information ...
Guido Zampieri +6 more
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Journal of Dairy Science, 2023 : Mastitis, the most frequent disease in dairy cattle. Resistance to mastitis is a complex, polygenic trait controlled by several genes, each with small effects.
Saranya G. Narayana +10 more
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Evaluation of phenotype-driven gene prioritization methods for Mendelian diseases. [PDF]
Brief Bioinform, 2022 Jacobsen JOB +4 more
europepmc +3 more sources
Benchmarking network-based gene prioritization methods for cerebral small vessel disease. [PDF]
Brief Bioinform, 2021 Zhang H +8 more
europepmc +2 more sources
Frontiers in Aging Neuroscience, 2023 Brain aging is a complex biological process that is affected by both genetic background and environment. The transcriptomic analysis of aged human and rodent brains has been applied to identify age-associated molecular and cellular processes for which ...
Hyojung Kim +11 more
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The frequency of somatic mutations in cancer predicts the phenotypic relevance of germline mutations
Frontiers in Genetics, 2023 Genomic sequence mutations can be pathogenic in both germline and somatic cells. Several authors have observed that often the same genes are involved in cancer when mutated in somatic cells and in genetic diseases when mutated in the germline.
Edoardo Luigi Draetta +5 more
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Prioritization and Evaluation of Flooding Tolerance Genes in Soybean [Glycine max (L.) Merr.]
Frontiers in Genetics, 2021 Soybean [Glycine max (L.) Merr.] is one of the most important legume crops abundant in edible protein and oil in the world. In recent years there has been increasingly more drastic weather caused by climate change, with flooding, drought, and unevenly ...
Mu-Chien Lai +5 more
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