Results 41 to 50 of about 2,805,831 (274)
Agronomy, 2019 Maize (Zea mays L.) is one of the most crucial crops for global food security worldwide. For this reason, many efforts have been undertaken to address the efficient utilization of germplasm collections.
Carlos Maldonado +4 more
doaj +1 more source
A guide to web tools to prioritize candidate genes [PDF]
Briefings in Bioinformatics, 2010 Finding the most promising genes among large lists of candidate genes has been defined as the gene prioritization problem. It is a recurrent problem in genetics in which genetic conditions are reported to be associated with chromosomal regions. In the last decade, several different computational approaches have been developed to tackle this challenging
Léon-Charles Tranchevent +5 more
openaire +3 more sources
Knowledge-guided gene prioritization.
, 2020 (A) In standard mode (top), each gene’s expression is tested for association with phenotypic labels, e.g., with a t test. In the (bottom) knowledge-guided mode (ProGENI algorithm), each gene’s expression is first transformed by taking into account ...
Krishna R. Kalari (8266770) +27 more
core +1 more source
Frontiers in MedicineBackgroundKnowledge-driven prioritization of candidate genes derived from large-scale molecular profiling data for targeted transcriptional profiling assays is challenging due to the vast amount of biomedical literature that needs to be harnessed.
Basirudeen Syed Ahamed Kabeer +6 more
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Analysis of the robustness of network-based disease-gene prioritization methods reveals redundancy in the human interactome and functional diversity of disease-genes. [PDF]
PLoS ONE, 2014 Complex biological systems usually pose a trade-off between robustness and fragility where a small number of perturbations can substantially disrupt the system.
Emre Guney, Baldo Oliva
doaj +1 more source
Prioritization of Candidate Genes Through Boolean Networks
, 2022 The in silico detection of master regulator genes is a popular attempt at speeding up drug development. These genes might be directly related to the onset of the disease, or may act on one pathway which counteracts the associated symptoms. Then, one could perhaps screen drugs to select chemical compounds targeting these genes.
Réda, Clémence +1 more
openaire +4 more sources
Drug-gene target prioritization.
, 2018 Drug-gene target prioritization.
Rozemarijn S. van Rijn (4898842) +10 more
core +1 more source
USEPA/Multiscale-Landscape-Prioritization-Code: Multiscale-Landscape-Prioritization-Code
, 2022 Public release of Multiscale-Landscape-Prioritization ...
Marc Weber
core +1 more source
Advanced Genetics, 2020 Despite an explosive growth of next‐generation sequencing data, genome diagnostics only provides a molecular diagnosis to a minority of patients. Software tools that prioritize genes based on patient symptoms using known gene‐disease associations may ...
K. Joeri van derVelde +9 more
doaj +1 more source