Results 21 to 30 of about 5,314,306 (291)

Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-Lymphocyte responses in infected African and Caucasoid adults and children [PDF]

, 2000
Cytotoxic T-lymphocyte (CTL) activity plays a central role in control of viral replication and in determining outcome in cases of human immunodeficiency virus type 1 (HIV-1) infection.
Ogg, GS, Coovadia, HM, O'Callaghan, CA, Kalams, SA, Mngqundaniso, N., Altfeld, M.A., Hammond, M., He, S, He, S., O'Callaghan, C.A., Tang, Y, Burchett, S.A., Walker, B.D., Rosenberg, ES, Burchett, SA, Pelton, SI, McIntosh, K, Annamalai, K, Annamalai, K., Cao, H, Walker, BD, Bunce, M, McIntosh, K., Coovadia, H.M., Kalams, S.A., Rosenberg, E.S., Govender, U., Brander, C, Goulder, P.J.R., Brander, C., Goulder, PJ, Hammond, M, O'Callaghan, Christopher, Mngqundaniso, N, Cao, H., Altfeld, MA, Ogg, G.S., Hartman, K.E., Pelton, S.I., Govender, U, Hartman, KE, Tang, Y., Bunce, M.   +42 more
core   +1 more source

Toll-like receptor agonists enhance HIV-specific T cell response mediated by plasmacytoid dendritic cells in diverse HIV-1 disease progression phenotypesResearch in context

EBioMedicine, 2023
Summary: Background: Plasmacytoid dendritic cells (pDCs) sense viral and bacterial products through Toll-like receptor (TLR)-7 and -9 and translate this sensing into Interferon-α (IFN-α) production and T-cell activation.
Maria R. Jimenez-Leon, Carmen Gasca-Capote, Laura Tarancon-Diez, Beatriz Dominguez-Molina, Macarena Lopez-Verdugo, Ryan Ritraj, Isabel Gallego, Ana I. Alvarez-Rios, Joana Vitalle, Sara Bachiller, María Inés Camacho-Sojo, Alberto Perez-Gomez, Nuria Espinosa, Cristina Roca-Oporto, Mohamed Rafii-El-Idrissi Benhnia, Alicia Gutierrez-Valencia, Luis F. Lopez-Cortes, Ezequiel Ruiz-Mateos   +17 more
doaj   +1 more source

Imperfect DNA mirror repeats in the gag gene of HIV-1 (HXB2) identify key functional domains and coincide with protein structural elements in each of the mature proteins

Virology Journal, 2007
Background A DNA mirror repeat is a sequence segment delimited on the basis of its containing a center of symmetry on a single strand, e.g. 5'-GCATGGTACG-3'. It is most frequently described in association with a functionally significant site in a genomic
Lang Dorothy M
doaj   +1 more source

Integrating Retroviral Cassette Extends Gene Delivery of HSV-1 Expression Vectors to Dividing Cells

BioTechniques, 2001
Retroviral vectors have long been used in a wide variety of gene transfer applications but have certain drawbacks, such as small cargo size, limited tropism, and low titers.
Pablo de Felipe, Marta Izquierdo, Francisco Wandosell, Filip Lim   +3 more
doaj   +1 more source

Evolution and phylogeny of insect endogenous retroviruses

BMC Evolutionary Biology, 2001
Background The genome of invertebrates is rich in retroelements which are structurally reminiscent of the retroviruses of vertebrates. Those containing three open reading frames (ORFs), including an env-like gene, may well be considered as endogenous ...
Pélisson Alain, Terzian Christophe, Bucheton Alain   +2 more
doaj   +1 more source

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]

, 2010
Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael, Karl Salzwedel, Salzwedel Karl, Catherine S. Adamson, Eric O. Freed, Sakalian, M, Michael Sakalian, Adamson, Catherine S, Salzwedel, K, Freed Eric O, Freed, E.O., Adamson Catherine S   +11 more
core   +1 more source

Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles [PDF]

, 2006
Includes bibliographical references (leaves 114-128).In this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a ...
Halsey, Richard James
core   +1 more source

Functional association between the nef gene product and gag‐pol region of HIV‐1

FEBS Letters, 2000
Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV‐1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions of both clones were comparable ...
Ono, Takeshi, Iwatani, Yasumasa, Nishimura, Akiko, Ishimoto, Akinori, Sakai, Hiroyuki   +4 more
openaire   +2 more sources

Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly

Retrovirology, 2011
Background The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains.
Solbak Sara MØ, Studtrucker Nicole, Schmidt Kerstin, Rauch Pia, Hahn Friedrich, Hahn Sabine, Neumann Liane, Votteler Jörg, Fossen Torgils, Henklein Peter, Ott David E, Holland Gudrun, Bannert Norbert, Schubert Ulrich   +13 more
doaj   +1 more source

Dynamic Post-Transcriptional Regulation of HIV-1 Gene Expression

Biology, 2012
Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. Basal transcription of the integrated provirus generates early transcripts that encode for the viral products Tat and Rev.
Alessandro Marcello, Anna Kula
doaj   +1 more source