Results 41 to 50 of about 5,314,306 (291)

Genetic diversity and primary resistance among HIV-1-positive patients from Maringá, Paraná, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2012
The objective of this study is to identify subtypes of Human Immunodeficiency Virus type 1 (HIV-1) and to analyze the presence of mutations associated to antiretroviral resistance in the protease (PR) and reverse transcriptase (RT) regions from 48 HIV-1 ...
Karine Vieira Gaspareto, Flávia Myrian Martins de Almeida Mello, José Ricardo Colleti Dias, Vera Alice Fernandes Meneguetti, Marta Evelyn Giansante Storti, João Leandro de Paula Ferreira, André Minhoto Lança, Rosângela Rodrigues, Luis Fernando de Macedo Brígido, Jorge Juarez Vieira Teixeira, Dennis Armando Bertolini   +10 more
doaj   +1 more source

Identification of the messenger RNAs coding for the gag and env gene products of the murine mammary tumor virus [PDF]

Proceedings of the National Academy of Sciences, 1979
Full-length (35S) genomic RNA from murine mammary tumor virus (MuMTV) was translated in vitro , using a reticulocyte lysate system, into proteins of 105,000, 75,000, 65,000, 35,000, and 27,000 daltons. These proteins were all immunoprecipitable with a monospecific antiserum to the major viral
Sen, G C, Smith, S W, Marcus, S L, Sarkar, N H   +3 more
openaire   +2 more sources

Vírus da artrite encefalite caprina: isolamento e caracterização de parte do gene gag

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2004
Amostras de sangue de 12 animais soropositivos pelo teste de imunodifusão em gel de agarose e que não apresentavam sinais clínicos sugestivos de infecção pelo vírus da artrite-encefalite caprina (CAEV) foram coletadas para isolamento viral.
P.P. Lima, M.A. Rocha, D. Stancek, A.M.G. Gouveia, G.D.R. Oliveira   +4 more
doaj   +1 more source

Rauscher leukemia virus populations enriched for "immature" virions contain increased amounts of P70, the gag gene product [PDF]

Journal of Virology, 1978
Preparations of Rauscher leukemia virus (RLV) that had relatively low, intermediate, or high levels of P70 (the gag gene product) on sodium dodecyl sulfatepolyacrylamide gel electrophoresis were examined by thin-section electron microscopy. A direct correlation was found between the number of immature virions in the RLV preparation and the amount of ...
R B, Luftig, Y, Yoshinaka
openaire   +2 more sources

Molecular Mechanisms Involved in the Differential Expression of gag Gene Products by Clonal Isolates of a Primate Sarcoma Virus [PDF]

Journal of Virology, 1978
Clonal isolates of an early passage stock of woolly monkey sarcoma virus (WSV) have been shown to code for different numbers of woolly monkey helper leukemia virus gag gene products. In the present report, the molecular mechanisms responsible for their differential expression of gag gene ...
K C, Robbins, H, Okabe, S R, Tronick, R V, Gilden, S A, Aaronson   +4 more
openaire   +2 more sources

Dynamics of HIV-1 assembly and release. [PDF]

, 2009
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and ...
Kräusslich Hans-Georg, Barbara Müller, William J. Godinez, Bräuchle Christoph, Müller, Barbara, Rohr Karl, Karl Rohr, Godinez, William J., William J Godinez, Lampe Marko, Eils, Roland, Godinez William J., Roland Eils, Rohr, Karl, Lampe, Marko, Ivanchenko Sergey, Lamb, Don C., Don C. Lamb, Marko Lampe, Bräuchle, Christoph, Eils Roland, Lamb Don C., Hans-Georg Kräusslich, Christoph Bräuchle, Kräusslich, Hans-Georg, Sergey Ivanchenko, Ivanchenko, Sergey, Don C Lamb, Müller Barbara   +28 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Studies on processing, particle formation, and immunogenicity of the HIV-1gag gene product: a possible component of a HIV vaccine [PDF]

Archives of Virology, 1992
Antigens in a particulate conformation were shown to be highly immunogenic in mammals. For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expression systems: recombinant bacteria, vaccinia- and baculoviruses were established encoding the entire ...
R, Wagner, H, Fliessbach, G, Wanner, M, Motz, M, Niedrig, G, Deby, A, von Brunn, H, Wolf   +7 more
openaire   +4 more sources

Synapomorphic Patterns in HIV Gag Gene Sequences [PDF]

, 2021
The Human Immunodeficiency Virus (HIV) is globally distributed and effects millions of people worldwide. Better understanding the global distribution and diversity of the HIV virus allows for more accurate treatment, and tracing to be followed more ...
Elsey, Samantha
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source