Results 51 to 60 of about 5,314,306 (291)

Subtype-associated differences in HIV-1 reverse transcription affect the viral replication

Retrovirology, 2010
Background The impact of the products of the pol gene, specifically, reverse transcriptase (RT) on HIV-1 replication, evolution, and acquisition of drug resistance has been thoroughly characterized for subtype B.
Feng Yanjun, Waltke Mackenzie, Iordanskiy Sergey, Wood Charles   +3 more
doaj   +1 more source

A new role for clathrin adaptor proteins 1 and 3 in lipoplex trafficking [PDF]

, 2014
Intracellular protein trafficking through secretory and endocytic pathways depends on the function of adaptor proteins that bind motifs on cargo proteins.
Gumbs, Jade, Emma C Anderson, Alford, Justine E., Jade Gumbs, Anderson, Emma C., Emma C. Anderson, Justine E Alford, Justine E. Alford   +7 more
core   +2 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Rous sarcoma virus expression in Saccharomyces cerevisiae: processing and membrane targeting of the gag gene product

Journal of Virology, 1990
In avian cells, the product of the gag gene of Rous sarcoma virus, Pr76gag, has been shown to be targeted to the plasma membrane, to form virus particles, and then to be processed into mature viral gag proteins. To explore how these phenomena may be dependent upon cellular (host) factors, we expressed the Rous sarcoma virus gag gene in a lower ...
Bonnet, Daniel André Paul, Spahr, Pierre-François   +1 more
openaire   +4 more sources

Estudo da resposta imune contra o antígeno Gag de HIV-1 no trato genital feminino murino induzida pela administração de adenovírus recombinantes [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010AIDS é um dos principais problemas de saúde pública atuais e acredita-se que a epidemia somente será controlada com uma vacina capaz
Haut, Larissa Herkenhoff
core  

Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]

, 2012
Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson, Adamson, Catherine S   +1 more
core   +1 more source

Functional Differentiation of Type II and Type I Collagen Articular Models in Synovial Fluid Film Formation and Recombinant Equine Lubricin Retention

Advanced Functional Materials, EarlyView.
Collagen II coatings support the formation of synovial fluid nanofilms, while collagen I coatings do not. Both bind recombinant equine lubricin similarly. These findings may help explain articular cartilage surface joint dysfunction, inform biomaterial design for synovial joint repair, and expand on lubricin‐based osteoarthritis therapies.
Diego R. Jaramillo Pinto, Nicolas L. Mendoza, Syeda Tajin Ahmed, Yidan Wen, Lenka Vitkova, Spencer M. Witt, Kaleb A. Cutter, Ummay Honey, Matthew J. Paszek, Heidi L. Reesink, Lawrence J. Bonassar, Kevin De France, Roberto C. Andresen Eguiluz   +12 more
wiley   +1 more source

A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: Potential impact on CTL epitopes

Virology Journal, 2008
The enormous genetic variability reported in HIV-1 has posed problems in the treatment of infected individuals. This is evident in the form of HIV-1 resistant to antiviral agents, neutralizing antibodies and cytotoxic T lymphocytes (CTLs) involving ...
Collman Ronald G, Cristillo Anthony, Kalyanaraman Vaniambadi S, Datta Debduti, Boyd Anne, Kannan Aarthi, Mahalingam Sundarasamy, Ayyavoo Velpandi, Srinivasan Alagarsamy, Morellet Nelly, Sawaya Bassel E, Murali Ramachandran   +11 more
doaj   +1 more source

Gag-H protein expression with anti-Gag-H clone 14H11G1.

, 2016
Overlay of histograms obtained by flow cytometric analyses of 11 CRC cell lines with no primary antibody (filled light grey surface), irrelevant antibody (anti-His; 2G2B3; grey line) and anti-Gag-H antibody (clone 14H11G1; black line) are presented in ...
Michael Linnebacher (180341), Maja Hühns (781392), Mathias Krohn (443089), Christina S. Mullins (2633872), Sven Peters (772641), Michèle Guillotte (2633866), Valérie Cheynet (2633875), Sandrine Ducrot (2633878), Guy Oriol (2633869), François Mallet (15409)   +9 more
core   +1 more source