Results 61 to 70 of about 5,314,306 (291)

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, EarlyView.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source

A Single-Nucleotide Synonymous Mutation in the gag Gene Controlling Human Immunodeficiency Virus Type 1 Virion Production [PDF]

Journal of Virology, 2007
ABSTRACT Viral factors as well as host ones play major roles in the disease progression of human immunodeficiency virus type 1 (HIV-1) infection. We have examined cytotoxic T-lymphocyte activity and HIV-1 DNA PCR results of 312 high-risk seronegative drug users in northern Thailand and identified four seronegative cases positive ...
Takaichi, Hamano, Kazuhiro, Matsuo, Yurina, Hibi, Ann Florence B, Victoriano, Naoko, Takahashi, Yosio, Mabuchi, Tsuyoshi, Soji, Shinji, Irie, Pathom, Sawanpanyalert, Hideki, Yanai, Takashi, Hara, Shudo, Yamazaki, Naoki, Yamamoto, Takashi, Okamoto   +13 more
openaire   +2 more sources

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Gag-ABCE1 colocalization in situ upon provirus expression.

, 2018
(A) PLA was used to detect regions in which Gag is within 40 nm from ABCE1 in situ, with concurrent αGag IF for quantification of intracellular Gag levels. An experimental schematic for PLA methods is shown.
Brook C. Barajas (5109236), Motoko Tanaka (507195), Daryl J. Phuong (5109230), Kasana Chutiraka (5109239), Jonathan C. Reed (5109242), Bridget A. Robinson (437733), Jaisri R. Lingappa (5109233)   +6 more
core   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

The ts110 Moloney Mouse Sarcoma Virus System: gag-mos Gene Products and Cellular Transformation

Journal of General Virology, 1985
Moloney murine sarcoma virus (Mo-MuSV) was one of the most widely studied mammalian retroviruses because it had acquired the cellular sequence called mos (Van Beveren et al., 1981a; Frankel & Fischinger, 1976), one of the first oncogenes identified. But difficulties with the low level of expression of the viral mos (v-mos) protein and apparent lack of ...
openaire   +2 more sources

Characterization of mouse mammary tumor virus gag-pro gene products and the ribosomal frameshift site by protein sequencing. [PDF]

Proceedings of the National Academy of Sciences, 1987
The synthesis of retroviral polyproteins that are the translational products of the genome-size mRNA is initiated in the upstream gag gene. The synthesis of the products of the protease gene (pro) and polymerase gene (pol) is regulated by translational suppression (in-frame read-through or frameshift) of termination codons as a strategy developed for ...
A, Hizi, L E, Henderson, T D, Copeland, R C, Sowder, C V, Hixson, S, Oroszlan   +5 more
openaire   +2 more sources

DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire [PDF]

, 2008
The majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets.
Buchan, Sarah L., Timothy J. Kendall, Philip D. Greenberg, Michelle L. Dossett, Stuart N. Dunn, Öhlén, Claes, Rice, Jason, Dossett, Michelle L., Dossett, Michelle L, Stevenson, Freda K., Kendall, Timothy J., Sarah L. Buchan, Freda K. Stevenson, Dunn, Stuart N, Greenberg, Philip D, Dunn, Stuart N., Greenberg, Philip D., Kendall, Timothy J; id_orcid, Stevenson, Freda K, Jason Rice, Buchan, Sarah L, Claes Öhlén   +21 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Genome-wide changes in expression profile of murine endogenous retroviruses (MuERVs) in distant organs after burn injury

BMC Genomics, 2007
Background Previous studies have shown that burn-elicited stress signals alter expression of certain murine endogenous retroviruses (MuERVs) in distant organs of mice.
Greenhalgh David, Thomas Rita, Fitzsimon Lauren, Chew Alex, Lee Young-Kwan, Cho Kiho   +5 more
doaj   +1 more source