Results 21 to 30 of about 131,368 (156)
Virology, 1997 cDNAs encoding the bovine immunodeficiency virus (BIV) transactivator gene (tat) were cloned from virally infected cells and characterized. BIV expresses two distinct tat mRNAs composed of three exons that are derived by alternative splicing. The BIV tat mRNA splice variants encode Tat proteins of 103 (Tat103) and 108 (Tat108) amino acids.
Fong, Steven E. +10 more
openaire +2 more sources
Therapeutic targets for HIV-1 infection in the host proteome
Retrovirology, 2005 Background Despite the success of HAART, patients often stop treatment due to the inception of side effects. Furthermore, viral resistance often develops, making one or more of the drugs ineffective.
Pumfery Anne +10 more
doaj +1 more source
HIV Silencing and Inducibility Are Heterogeneous and Are Affected by Factors Intrinsic to the Virus
mBio, 2019 Transcriptionally silent HIV proviruses form the major obstacle to eradicating HIV. Many studies of HIV latency have focused on the cellular mechanisms that maintain silencing of proviral DNA.
Nicholas J. Norton +4 more
doaj +1 more source
Role of cyclic AMP in the control of cell-specific gene expression [PDF]
, 1993 Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael +3 more
core +1 more source
Filtering "genic" open reading frames from genomic DNA samples for advanced annotation
BMC Genomics, 2011 Background In order to carry out experimental gene annotation, DNA encoding open reading frames (ORFs) derived from real genes (termed "genic") in the correct frame is required.
Sblattero Daniele +6 more
doaj +1 more source
Synthesis and bioactivity of erythro-nordihydroguaiaretic acid, threo-(–)-saururenin and their analogues [PDF]
Journal of the Serbian Chemical Society, 2010 Full details of the total syntheses of erythro-nordihydroguaiaretic acid, threo-(–)-saururenin and their analogues are presented. The syntheses were based on a unified synthetic strategy involving the Stobbe reaction, alkylation to construct the skeleton
YAMU XIA +4 more
doaj
Journal of General Virology, 2001 Human herpesvirus-8 (HHV-8) is a lymphotropic virus associated with several AIDS-related neoplasms. Two ORFs play a critical role in the regulation of virus replication: ORF50, encoding an immediate-early transcriptional activator, and ORF57, encoding a post-transcriptional regulator.
CASELLI, Elisabetta +5 more
openaire +2 more sources
Journal of Neuroinflammation, 2011 Background Human immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia in the CNS, and subsequent secretion of high levels of neurotoxic ...
Maggirwar Sanjay B +6 more
doaj +1 more source
The Saccharomyces cerevisiae SEC14 Gene Encodes a Cytosolic Factor That Is Required for Transport of Secretory Proteins from the Yeast Golgi Complex [PDF]
, 1989 We have obtained and characterized a genomic clone of SEC14, a Saccharomyces cerevisiae gene whose product is required for export of yeast secretory proteins from the Golgi complex.
Bankaitis, Vytas A. +3 more
core +1 more source
Pathological and molecular study of mycotic abortion in ewes
Kufa Journal for Veterinary Medical Sciences, 2013 The aims of the present study is to isolate the fungal species associated with ewe abortion and to examine the histopathological changes in the placenta associated with fungal isolates .In addition to study the genetic information of TNF alpha ...
Bushra Hamza Faris +2 more
doaj +1 more source