Results 61 to 70 of about 271,468 (359)

Clinicopathological practice in the differential diagnosis of mucoepidermoid carcinoma from neoplasms with mucinous component

Chronic Diseases and Translational Medicine, 2023
Background The differential diagnosis of mucoepidermoid carcinoma (MEC) from neoplasm undergoing mucinous features brings more pitfalls to pathologists.
Yuelu Zhu, Yan Li, Lei Guo, Wenbin Li, Jiali Mu, Haifeng Zhang, Xin Li, Jianming Ying, Haizhen Lu   +8 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

On a break with the X: the role of repair of double-stranded DNA breaks in X-linked disease [PDF]

, 2012
The problem of managing free reactive DNA ends in eukaryotic cells has resulted in the development of a number of mechanisms in order to ensure that free ends are rendered non-reactive, or that the double-strand DNA breaks generating the free ends are ...
Cecceroni, Lucia, De Caris, Laura, Tummala, Hemanth   +2 more
core   +4 more sources

CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies [PDF]

, 2021
Eitan Halper‐Stromberg, Chad M. McCall, Lisa Haley, Ming-Tseh Lin, Samantha L. Vogt, Christopher D. Gocke, James R. Eshleman, Wendy Stevens, Neil Martinson, Marta Epeldegui, Matthias Holdhoff, Chetan Bettegowda, Michael Glantz, Richard F. Ambinder, Rena R. Xian   +14 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The mitochondrial genome of a social aphid, Pseudoregma bambucicola (Hemiptera: Aphididae: Hormaphidinae)

Mitochondrial DNA. Part B. Resources, 2019
In this study, the complete mitochondrial genome of the social aphid Pseudoregma bambucicola was assembled and annotated. The genome spans 16,631 bp in length with a high A + T content (85.1%), containing 13 protein-coding genes, 22 tRNA genes, two rRNA ...
Hui Zhang, Jun Deng, Qian Liu, Xiaolei Huang   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Hidden breakpoints in genome alignments

, 2012
During the course of evolution, an organism's genome can undergo changes that affect the large-scale structure of the genome. These changes include gene gain, loss, duplication, chromosome fusion, fission, and rearrangement.
A. Rambaut, A.C.E. Darling, A.E. Darling, A.L. Delcher, C.D. Greenman, D. Medini, E. Tannier, G. Fudenberg, M. Blanchette, M. Nowacki, M.A. Umbarger, S. De, S. Schwartz, S.V. Angiuoli, V. Kolmogorov   +14 more
core   +1 more source

Joining of Immunoglobulin Heavy Chain Gene Segments: Implications from a Chromosome with Evidence of Three D-JH Fusions [PDF]

, 1982
A chromosomal segment with a unique structure around the immunoglobulin heavy chain joining region (JH) has been molecularly cloned from an Abelson murine leukemia virus-transformed cell line.
Alt, Frederick W., Baltimore, David
core   +1 more source

The mitogenome of the scale insect Didesmococcus koreanus Borchsenius, 1955 (Coccoidea: Coccidae)

Mitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genome of Didesmococcus koreanus is described in this study. The complete mitogenome is a 15,162 bp circular DNA molecule with a high A + T content of 82.5%, containing the typical 37 genes.
Han Xu, Xiaochen Liu, Hu Li, Sanan Wu
doaj   +1 more source