Results 61 to 70 of about 150,131 (316)

Immunoglobulin lambda gene rearrangement can precede kappa gene rearrangement.

Developmental immunology, 1992
Immunoglobulin genes are generated during differentiation of B lymphocytes by joining gene segments. A mouse pre-B cell contains a functional immunoglobulin heavy-chain gene, but no light-chain gene. Although there is only one heavy-chain locus, there are two light-chain loci: kappa and lambda.
J, Berg, M, McDowell, H M, Jäck, M, Wabl   +3 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia

Advances in Hematology, 2009
In this study, Forty-one out of fifty-seven Tunisian children with B-lineage acute lymphoblastic leukemia (B-ALL), and without cytogenetically detectable recurrent abnormalities at the time of the diagnosis, were evaluated by fluorescence in situ ...
Abir Gmidène, Hatem Elghezal, Hlima Sennana, Yosra Ben Youssef, Balkiss Meddeb, Moez Elloumi, Abderrahim Khlif, Ali Saad   +7 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Lennert′s lymphoma: Clinicopathological profile of five cases

Indian Journal of Pathology and Microbiology, 2013
Background and Aim: Lennert′s lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS) rich in epithelioid histiocytes.
Sarda Parimal, Rekha Pai, Marie Therese Manipadam, Sheila Nair   +3 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes

Frontiers in Immunology, 2014
While most genes in the mammalian genome are transcribed from both parental chromosomes in cells where they are expressed, approximately 10% of genes are expressed monoallelically, so that any given cell will express either the paternal or maternal ...
Rena eLevin-Klein, Yehudit eBergman
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Recurrent CIC-rearranged sarcoma of central nervous system: a clinicopathological case report

Frontiers in Oncology
CIC-rearranged sarcoma (CRS) is a subgroup of small round blue cell tumors similar to Ewing’s sarcoma but lacking the EWSR1 gene translocation. It is characterized by a CIC gene rearrangement on chromosome 19q13, with the most common partner gene being ...
Shan Jiang, Shan Jiang, Shan Jiang, Shan Jiang, Kay Ka-Wai Li, Jingqi Hu, Jingqi Hu, Yun Guan, Yun Guan, Yun Guan, Rui-Ze Zhu, Rui-Ze Zhu, Rui-Ze Zhu, Rui-Ze Zhu, Hou-Shi Xu, Hou-Shi Xu, Hou-Shi Xu, Hou-Shi Xu, Mao-Yuan Sun, Mao-Yuan Sun, Mao-Yuan Sun, Mao-Yuan Sun, Bei-Ning Liu, Bei-Ning Liu, Bei-Ning Liu, Bei-Ning Liu, Hui-Hui Chai, Hui-Hui Chai, Hui-Hui Chai, Hui-Hui Chai, Yue Wang, Yue Wang, Yue Wang, Qi-Sheng Tang, Qi-Sheng Tang, Qi-Sheng Tang, Qi-Sheng Tang, Ho-Keung Ng, Zhi-Feng Shi, Zhi-Feng Shi, Zhi-Feng Shi, Zhi-Feng Shi   +41 more
doaj   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source