Results 91 to 100 of about 2,989,814 (357)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Associative memory in gene regulation networks

open access: yes, 2010
The pattern of gene expression in the phenotype of an organism is determined in part by the dynamical attractors of the organism’s gene regulation network.
Buckley, C. L.   +3 more
core  

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

open access: yes, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J.   +8 more
core   +1 more source

Eukaryotic gene regulation [PDF]

open access: yesChemistry & Biology, 2000
Basal Transcription Factor Informationhttp://tfiib.med.harvard.edu/transcription/basaltx.htmlEukaryotic Promoter Databasehttp://www.epd.isb-sib.ch/Transcriptional Regulatory Regions Databasehttp://www.bionet.nsc.ru/trrd/TRANSFAChttp://transfac.gbf.de/Homeodomain Resourcehttp://genome.nhgri.nih.gov/homeodomain/The Nuclear Receptor Resourcehttp://nrr ...
openaire   +2 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Frequency-modulated nuclear localization bursts coordinate gene regulation [PDF]

open access: yes, 2008
In yeast, the transcription factor Crz1 is dephosphorylated and translocates into the nucleus in response to extracellular calcium. Here we show, using time-lapse microscopy, that Crz1 exhibits short bursts of nuclear localization (typically lasting 2 ...
Cai, Long   +2 more
core   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

RNA-containing extracellular vesicles in infection

open access: yesRNA Biology
Extracellular vesicles (EVs) are membrane-bound particles released by cells that play vital roles in intercellular communication by transporting diverse biologically active molecules, including RNA molecules, including mRNA, miRNA, lncRNA, and other ...
Kayo Schemiko Almeida   +2 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Hydrogen magnetic reaction gene regulation

open access: yes, 2012
A new gene regulation system using weak magnetic field can induce the hydrogen magnetic reaction (HMR) in hydrogen atoms, and subsequently affect the electrostatic polarity of hydrogen bonds in DNA base pairs.
Kim, Yeon Sook   +2 more
core  

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