Results 101 to 110 of about 2,989,814 (357)

Motif Discovery through Predictive Modeling of Gene Regulation

open access: yes, 2005
We present MEDUSA, an integrative method for learning motif models of transcription factor binding sites by incorporating promoter sequence and gene expression data.
A. Battle   +15 more
core   +2 more sources

One-two punch mechanism of gene repression: a fresh perspective on gene regulation. [PDF]

open access: yes, 2017
Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another.
Tresenrider, Amy, Ünal, Elçin
core   +1 more source

TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

open access: yesJHEP Reports, 2020
Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown.
Carla Usai   +9 more
doaj  

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

open access: yesNature Communications, 2019
Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber   +7 more
doaj   +1 more source

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

open access: yeseLife, 2016
Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious assays ...
Hanneke Vlaming   +10 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

The regulation of Hox gene expression during animal development [PDF]

open access: yes, 2013
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns ...
Alonso, Claudio R, Mallo, Moisés
core   +1 more source

A Sendai virus-based expression system directs efficient induction of chondrocytes by transcription factor-mediated reprogramming

open access: yesScientific Reports
Cartilage rarely heals spontaneously once damaged. Osteoarthritis (OA) is the most common degenerative joint disease among the elderly; however, effective treatment for OA is currently lacking.
Jingwen Zhou   +5 more
doaj   +1 more source

ARID1A promotes genomic stability through protecting telomere cohesion

open access: yesNature Communications, 2019
Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in
Bo Zhao   +16 more
doaj   +1 more source

Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions

open access: yesPathogens, 2015
Hepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the hepadnaviridae family like hepatitis B virus (HBV) for its replication and formation of new virions.
Rafael Aldabe   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy