Results 161 to 170 of about 3,132,999 (350)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Effects of gene multiplication on flowering time regulation in spring and winter varieties of Brassica napus [PDF]

, 2017
David Jones
openalex  

A landscape of gene expression regulation for synovium in arthritis [PDF]

Feng Jiang, Shou‐Ye Hu, Wen Tian, Naining Wang, Ning Yang, Shan‐Shan Dong, Hui-Miao Song, Dajin Zhang, Hui-Wu Gao, Chen Wang, Hao Wu, Chang-Yi He, Dong‐Li Zhu, Xiaofeng Chen, Yan Guo, Zhi Yang, Tie‐Lin Yang   +16 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Differential Regulation of Genes for Cyclic-di-GMP Metabolism Orchestrates Adaptive Changes During Rhizosphere Colonization by Pseudomonas fluorescens

, 2019
Richard Little, Stuart Daniel Woodcock, Rosaria Campilongo, Rowena K. Y. Fung, Robert Heal, Libby Humphries, Alba Pacheco-Moreno, Stefan Paulusch, Egidio Stigliano, Eleni Vikeli, Danny Ward, Jacob G. Malone   +11 more
openalex   +1 more source

Effect of Melatonin on Ovarian Function by Over-expression and Down -Regulation of Genes Related to Steroidogenesis in Pinealectomized Rats [PDF]

, 2014
CC Maganhin, RS Simões, Girão JHRC, Luiz Fernando Portugal Fuchs, Sasso GRS, Carbonel AAF, LA Reis, MJ Simões, EC Baracat, JM Soares   +9 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes

, 2013
Sani Ismaila Muhammad, Maznah Ismail, Rozi Mahmud, Mohamed Al Saeed, Mustapha Umar Imam, Aminu Ishaka   +5 more
openalex   +2 more sources

P1485Changes of regional myocardial deformation induced by serelaxin reflect gene regulation in experimental heart failure model [PDF]

, 2017
Tomas Lapinskas, Jana Grune, Heike Meýborg, Ulrich Kintscher, Rolf Gebker, Burkert Pieske, Sebastian Kelle, Philipp Stawowy   +7 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source