Ir Gene Regulation at the Single Cell Level
Susan K. Pierce, Norman R. Klinman
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This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci+6 more
wiley +1 more source
A multi-tissue and -breed catalogue of chromatin conformations and their implications in gene regulation in pigs. [PDF]
Yin H+6 more
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Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
Acyl-CoA-binding proteins: bridging long-chain acyl-CoA metabolism to gene regulation. [PDF]
Wundersitz A+2 more
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Transcriptional Regulation of the Mercury-resistance Genes of Transposon Tn501 [PDF]
Peter A. Lund, S. J. Ford, Nathan Brown
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
CRISPR-Cas12i confers efficient genome editing and gene regulation in plants. [PDF]
He Y+6 more
europepmc +1 more source
Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation [PDF]
Israel Hanukoglu, Zelda HANUKOGLU
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