Results 71 to 80 of about 3,132,999 (350)

A role for p53 in telomere protection

Molecular & Cellular Oncology, 2017
Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Switching and diffusion models for gene regulation networks [PDF]

, 2009
We analyze a hierarchy of three regimes for modeling gene regulation. The most complete model is a continuous time, discrete state space, Markov jump process.
Cao Y., Desmond J. Higham, Somkid Intep, Xuerong Mao   +3 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

Nature Communications, 2020
SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional ...
Elena Grossi, Ivan Raimondi, Enrique Goñi, Jovanna González, Francesco P. Marchese, Vicente Chapaprieta, José I. Martín-Subero, Shuling Guo, Maite Huarte   +8 more
doaj   +1 more source

LINC00998‐encoded micropeptide SMIM30 promotes the G1/S transition of cell cycle by regulating cytosolic calcium level

Molecular Oncology, 2023
The biological functions of short open reading frame (sORF)‐encoded micropeptides remain largely unknown. Here, we report that LINC00998, a previously annotated lncRNA, was upregulated in multiple cancer types and the sORF on LINC00998 encoded a ...
Jin‐E Yang, Wang‐Jing Zhong, Jin‐Feng Li, Ying‐Ying Lin, Feng‐Ting Liu, Hao Tian, Ya‐Jing Chen, Xiao‐Yu Luo, Shi‐Mei Zhuang   +8 more
doaj   +1 more source

Genome-wide co-expression analysis in multiple tissues [PDF]

, 2008
Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis- and trans-acting, reflecting local and distant regulation of gene expression respectively.
Aitman, T.J., Cook, S.A., Dickens, N.J., Grieve, I.C., Hubner, N., Kren, V., Mangion, J., Petretto, E., Pravenec, M.   +8 more
core   +7 more sources

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Dualistic role of ZEB1 and ZEB2 in tumor progression

Biology Direct
It is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev, Alexandra A. Daks, Oleg Y. Shuvalov, Olga A. Fedorova, Nikolay B. Pestov, Tatyana V. Korneenko, Nickolai A. Barlev   +6 more
doaj   +1 more source

Transcriptional Regulation of Gene Expression in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1990
The only well-characterized study of gene expression in Tetrahymena thermophila (1) demonstrates that the temperature dependent expression of the Ser H3 gene is regulated at the level of mRNA stability.
Gorovsky, Martin A., Karrer, Kathleen M., Stargell, Laurie A.   +2 more
core   +1 more source