Results 71 to 80 of about 3,082,129 (201)

Stochastic models and numerical algorithms for a class of regulatory gene networks [PDF]

, 2008
Regulatory gene networks contain generic modules like those involving feedback loops, which are essential for the regulation of many biological functions.
Fournier, Thomas, Gabriel, Jean-Pierre, Galbete, Jose, Mazza, Christian, Mermod, Nicolas, Pasquier, Jerome   +5 more
core   +2 more sources

NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo

Journal of Lipid Research, 2018
Transcriptional coactivator PPAR γ coactivator (PGC)-1α and its splice variant N-terminal (NT)-PGC-1α mediate transcriptional regulation of brown adipose tissue (BAT) thermogenesis in response to changes in ambient temperature.
Jihyun Kim, Min Sung Park, Kyoungsoo Ha, Chulhong Park, Jisu Lee, Randall L. Mynatt, Ji Suk Chang   +6 more
doaj   +1 more source

Hydrogen magnetic reaction gene regulation

, 2012
A new gene regulation system using weak magnetic field can induce the hydrogen magnetic reaction (HMR) in hydrogen atoms, and subsequently affect the electrostatic polarity of hydrogen bonds in DNA base pairs.
Kim, Yeon Sook, Lee, Dae Gwan, Lee, Suk Keun   +2 more
core  

Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Nature Communications
ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding ...
Dong Wang, Fan Bu, Ge Yang, Bin Liu
doaj   +1 more source

Associative memory in gene regulation networks

, 2010
The pattern of gene expression in the phenotype of an organism is determined in part by the dynamical attractors of the organism’s gene regulation network.
Buckley, C. L., Davies, Adam, Mills, Rob, Watson, Richard   +3 more
core  

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

eLife, 2016
Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious assays ...
Hanneke Vlaming, Thom M Molenaar, Tibor van Welsem, Deepani W Poramba-Liyanage, Desiree E Smith, Arno Velds, Liesbeth Hoekman, Tessy Korthout, Sjoerd Hendriks, AF Maarten Altelaar, Fred van Leeuwen   +10 more
doaj   +1 more source

A Sendai virus-based expression system directs efficient induction of chondrocytes by transcription factor-mediated reprogramming

Scientific Reports
Cartilage rarely heals spontaneously once damaged. Osteoarthritis (OA) is the most common degenerative joint disease among the elderly; however, effective treatment for OA is currently lacking.
Jingwen Zhou, Yuya Sekiguchi, Masayuki Sano, Ken Nishimura, Koji Hisatake, Aya Fukuda   +5 more
doaj   +1 more source

RNA-containing extracellular vesicles in infection

RNA Biology
Extracellular vesicles (EVs) are membrane-bound particles released by cells that play vital roles in intercellular communication by transporting diverse biologically active molecules, including RNA molecules, including mRNA, miRNA, lncRNA, and other ...
Kayo Schemiko Almeida, Suélen Andreia Rossi, Lysangela Ronalte Alves   +2 more
doaj   +1 more source

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Nature Communications, 2019
Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber, Leticia Odriozola, Javier Martínez-García, Veronica Ferrer, Anne Douar, Bernard Bénichou, Gloria González-Aseguinolaza, Cristian Smerdou   +7 more
doaj   +1 more source

Spatial mechanisms of gene regulation in metazoan embryos [PDF]

, 1991
The basic characteristics of embryonic process throughout Metazoa are considered with focus on those aspects that provide insight into how cell specification occurs in the initial stages of development.
Davidson, Eric H.
core