Results 81 to 90 of about 3,082,129 (201)

Extending the dynamic range of transcription factor action by translational regulation

, 2015
A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their
Bialek, William, Sokolowski, Thomas R., Tkačik, Gašper, Walczak, Aleksandra M.   +3 more
core   +1 more source

ARID1A promotes genomic stability through protecting telomere cohesion

Nature Communications, 2019
Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in
Bo Zhao, Jianhuang Lin, Lijie Rong, Shuai Wu, Zhong Deng, Nail Fatkhutdinov, Joseph Zundell, Takeshi Fukumoto, Qin Liu, Andrew Kossenkov, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Ronny Drapkin, Paul M. Lieberman, Cory T. Abate-Shen, Rugang Zhang   +16 more
doaj   +1 more source

Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions

Pathogens, 2015
Hepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the hepadnaviridae family like hepatitis B virus (HBV) for its replication and formation of new virions.
Rafael Aldabe, Lester Suárez-Amarán, Carla Usai, Gloria González-Aseguinolaza   +3 more
doaj   +1 more source

Structure of the Nipah virus polymerase phosphoprotein complex

Nature Communications
The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
Ge Yang, Dong Wang, Bin Liu
doaj   +1 more source

Structure of the measles virus ternary polymerase complex

Nature Communications
Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj   +1 more source

Author Correction: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

Nature Communications, 2022
Federico Pelisch, Remi Sonneville, Ehsan Pourkarimi, Ana Agostinho, J. Julian Blow, Anton Gartner, Ronald T. Hay   +6 more
doaj   +1 more source

A CUG codon-adapted anchor-away toolkit for functional analysis of genes in Candida albicans

mSphere
Promoter shutoff of essential genes in the diploid Candida albicans has often been insufficient to create tight, conditional null alleles due to leaky expression and has been a stumbling block in pathogenesis research.
Basharat Bashir Teli, Priyanka Nagar, Yumnam Priyadarshini, Poonam Poonia, Krishnamurthy Natarajan   +4 more
doaj   +1 more source

Quantification of transcript isoforms at the single-cell level using SCALPEL

Nature Communications
Single-cell RNA sequencing (scRNA-seq) facilitates the study of transcriptome diversity in individual cells. Yet, many existing methods lack sensitivity and accuracy.
Franz Ake, Marcel Schilling, Sandra M. Fernández-Moya, Akshay Jaya Ganesh, Ana Gutiérrez-Franco, Lei Li, Mireya Plass   +6 more
doaj   +1 more source

An Improved m6A-ELISA for Quantifying N6-methyladenosine in Poly(A)-purified mRNAs

Bio-Protocol
N6-methyladenosine (m6A) is an abundant internal mRNA modification with roles in regulating cellular and organismal physiology, including development, differentiation, and disease. The deposition of m6A is highly regulated, with various m6A levels across
Wei Chan, Waleed Albihlal, Folkert Van Werven   +2 more
doaj   +1 more source

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Nature Communications
DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ).
Xabier Vergara, Anna G. Manjón, Marcel de Haas, Ben Morris, Ruben Schep, Christ Leemans, Anoek Friskes, Roderick L. Beijersbergen, Mathijs A. Sanders, René H. Medema, Bas van Steensel   +10 more
doaj   +1 more source