Results 111 to 120 of about 8,545,689 (298)
Scientific Reports, 2017 Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs.
Xiaodong Jia +9 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Gene regulatory network model and evolutionary model.
, 2023 Gene regulatory network model and evolutionary model.
Tanvi Madaan (15332567) +2 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Neoliberalism or Regulatory Capitalism? [PDF]
Jacint Jordana and David Levi-Faur have provided systematic evidence that, since 1980, states have become rather more preoccupied with steering and less with rowing.
Braithwaite, John +1 more
core
Dynamical approaches to modeling developmental gene regulatory networks
The network of interacting regulatory signals within a cell comprises one of the most complex and powerful computational systems in biology. Gene regulatory networks play a key role in transforming the information encoded in a genome into morphological ...
Geard, Nicholas, Willadsen, Kai
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Dynamics of molecular fluctuations in gene regulatory networks
, 2009 The components that are central to cellular processing are proteins, whose production is regulated by other proteins known as transcription factors. Proteins are products of genes that regulate the expression of one another, thereby forming large gene ...
Pakka, Vijayanarasimha Hindupur
core +1 more source
Approaches for Benchmarking Single-Cell Gene Regulatory Network Methods
Bioinformatics and Biology InsightsGene regulatory networks are powerful tools for modeling genetic interactions that control the expression of genes driving cell differentiation, and single-cell sequencing offers a unique opportunity to build these networks with high-resolution genomic ...
Karamveer, Yasin Uzun
doaj +1 more source
Feedback control of pluripotency in embryonic stem cells: Signaling, transcription and epigenetics
Stem Cell Research, 2018 Embryonic stem cells (ESCs) can proliferate and self-renew, maintaining their pluripotency status in vitro for a long period of time. Pluripotent states of ESCs in vitro are supported by a network of signaling, transcriptional and epigenetic regulatory ...
Dmitri Papatsenko +2 more
doaj +1 more source