Results 111 to 120 of about 474,387 (314)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Statistical reconstruction of transcription factor activity using Michaelis-Menten kinetics

, 2007
Summary. The basic building block of a gene regulatory network consists of a gene encoding a transcription factor (TF) and the gene(s) it regulates. Considerable efforts have been directed recently at devising experiments and algorithms to determine TFs
Smith, C.P.,, Smith, C.P., Vinciotti, V., Smith, C P, Khanin, R.,, Khanin, Raya, Mersinias, V., Wit, E.,, Vinciotti, V.,, Wit, Ernst, Vinciotti, V, Mersinias, V.,, Mersinias, V, Smith, CP, Khanin, R, Wit, E, Khanin, R.   +16 more
core   +1 more source

Fused Regression for Multi-source Gene Regulatory Network Inference.

PLoS Computational Biology, 2016
Understanding gene regulatory networks is critical to understanding cellular differentiation and response to external stimuli. Methods for global network inference have been developed and applied to a variety of species.
Kari Y Lam, Zachary M Westrick, Christian L Müller, Lionel Christiaen, Richard Bonneau   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The DtxR protein acting as dual transcriptional regulator directs a global regulatory network involved in iron metabolism of Corynebacterium glutamicum

, 2006
Brune I, Werner H, Hüser AT, Kalinowski J, Pühler A, Tauch A. The DtxR protein acting as dual transcriptional regulator directs a global regulatory network involved in iron metabolism of Corynebacterium glutamicum. BMC Genomics. 2006;7(1): 21.Background:
Hüser, Andrea T., Brune, Iris, Kalinowski Jörn, Werner, Hendrikje, Andreas Tauch, Tauch Andreas, Hüser Andrea T, Hendrikje Werner, Brune Iris, Iris Brune, Pühler, Alfred ; https://orcid.org/, AndreaT Hüser, Pühler Alfred, Tauch, Andreas, Werner Hendrikje, Kalinowski, Jörn, Alfred Pühler, Jörn Kalinowski   +17 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Modeling Dynamic Gene Expression in Streptomyces Coelicolor: Comparing Single and Multi-Objective Setups

, 2020
"This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC)"-- This book serves as a handbook for gene regulatory network research using evolutionary algorithms, with ..
Laing, E, Smith, CP, Thomas, SA, jin, Y   +3 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks

, 2017
Here, we present the updated rSNPBase 3.0 database (http://rsnp3.psych.ac.cn), which provides human SNP-related regulatory elements, element-gene pairs and SNP-based regulatory networks.
Jing Wang, Liyuan Guo, Guo, Liyuan, Wang, Jing   +3 more
core   +1 more source

hlh-1 and the C. elegans Body Wall Muscle Transcriptional Differentiation Network [PDF]

, 2011
To understand the structure and function of gene regulatory networks, it is important to first catalogue the components. Measurable constituents of networks include cis-regulatory elements, identified by their conservation and ability to drive expression;
Kuntz, Steven Gregory
core   +1 more source