Results 91 to 100 of about 8,163,121 (296)

Fused Regression for Multi-source Gene Regulatory Network Inference.

PLoS Computational Biology, 2016
Understanding gene regulatory networks is critical to understanding cellular differentiation and response to external stimuli. Methods for global network inference have been developed and applied to a variety of species.
Kari Y Lam, Zachary M Westrick, Christian L Müller, Lionel Christiaen, Richard Bonneau   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks

PLOS Computational Biology, 2015
Human gene regulatory networks (GRN) can be difficult to interpret due to a tangle of edges interconnecting thousands of genes. We constructed a general human GRN from extensive transcription factor and microRNA target data obtained from public databases.
Vipin Narang, Muhamad Azfar Ramli, Amit Singhal 0003, Pavanish Kumar, Gennaro de Libero, Michael Poidinger, Christopher P. Monterola   +6 more
openaire   +5 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Differential System Approach to Gene Regulatory Network Modeling

AppliedMath
The system of ordinary differential equations that arises in models of genetic networks is considered. This system has both nonlinear and linear parts. As a nonlinear part, we use a piecewise linear function. This allows us to treat systems with multiple
Olga Kozlovska, Felix Sadyrbaev
doaj   +1 more source

D3GRN: a data driven dynamic network construction method to infer gene regulatory networks

BMC Genomics, 2019
Background To infer gene regulatory networks (GRNs) from gene-expression data is still a fundamental and challenging problem in systems biology. Several existing algorithms formulate GRNs inference as a regression problem and obtain the network with an ...
Xiang Chen, Min Li, Ruiqing Zheng, Fang-Xiang Wu, Jianxin Wang   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Linking Cytoscape and the corynebacterial reference database CoryneRegNet [PDF]

, 2008
Baumbach J, Apeltsin L. Linking Cytoscape and the corynebacterial reference database CoryneRegNet. BMC Genomics. 2008;9(1): 184.Background: Recently, the research community has seen an influx of data relating to transcriptional regulatory interactions of
Baumbach Jan, Jan Baumbach, Apeltsin, Leonard, Baumbach, Jan, Apeltsin Leonard, Leonard Apeltsin   +5 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Hopf bifurcation in a gene regulatory network model : molecular movement causes oscillations [PDF]

, 2014
M.A.J.C. and M.S. gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, “M5CGS — From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread”. M.S.
Ptashnyk, Mariya, Marc Sturrock, Ptashnyk, Mariya; id_orcid, Chaplain, Mark A. J., Sturrock, Marc, Mark Chaplain, Chaplain, Mark, Mariya Ptashnyk A, Mark Chaplain A, Marc Sturrock B, Mariya Ptashnyk, Ptashnyk, M, Chaplain, M, Sturrock, M   +13 more
core   +1 more source