Results 71 to 80 of about 8,545,689 (298)
Co-expression pan-network reveals genes involved in complex traits within maize pan-genome
BMC Plant Biology, 2022 Background With the advances in the high throughput next generation sequencing technologies, genome-wide association studies (GWAS) have identified a large set of variants associated with complex phenotypic traits at a very fine scale.
H. Busra Cagirici +2 more
doaj +1 more source
IEEE Access, 2023 The study of dynamic behavior can better understand the mechanism of genetic regulatory network. DNA is transcribed into mRNA and mRNA is translated into proteins. The process takes time to complete.
Yumei Lin, Yuan Ma, Yunxian Dai
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Quantitative analysis of the ThrbCRM1-centered gene regulatory network
Biology Open, 2019 Enhancer activity is determined by both the activity and occupancy of transcription factors as well as the specific sequences they bind. Experimental investigation of this dynamic requires the ability to manipulate components of the system, ideally in as
Benjamin Souferi, Mark M. Emerson
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Tightly regulated expression of Autographa californica multicapsid nucleopolyhedrovirus immediate early genes emerges from their interactions and possible collective behaviors. [PDF]
PLoS ONE, 2015 To infect their hosts, DNA viruses must successfully initiate the expression of viral genes that control subsequent viral gene expression and manipulate the host environment.
Chikako Ono +5 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
BMC BioinformaticsBackground Gene regulatory networks (GRNs) involve complex regulatory relationships between genes and play important roles in the study of various biological systems and diseases.
Yao Sun, Jing Gao
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Reconstruct gene regulatory network using slice pattern model
BMC Genomics, 2009 Background Gene expression time series array data has become a useful resource for investigating gene functions and the interactions between genes.
Yang Bo +6 more
doaj +1 more source