Results 51 to 60 of about 8,545,689 (298)

Research on Controllability of Gene Regulatory Network Based on Longest Control Chain [PDF]

Jisuanji gongcheng, 2018
In order to analyze the controllability of gene regulation network,in this paper,the gene regulatory network in human cell cycle is studied,and the structural control process of gene network is reconstructed based on the Boolean logic functions,which are
BAI Xueyi,GUO Binghui,LI Jiahui,ZHENG Zhiming
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Sea Urchin Regulome in Development [PDF]

, 2007
During development an organism undergoes many rounds of pattern formation, generating ever greater complexity with each ensuing round of cell division and specification.
Ashby, Meredith Howard
core   +1 more source

Metabolic constraint-based refinement of transcriptional regulatory networks. [PDF]

PLoS Computational Biology, 2013
There is a strong need for computational frameworks that integrate different biological processes and data-types to unravel cellular regulation. Current efforts to reconstruct transcriptional regulatory networks (TRNs) focus primarily on proximal data ...
Sriram Chandrasekaran, Nathan D Price
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Directed partial correlation : inferring large-scale gene regulatory network through induced topology disruptions [PDF]

, 2011
Inferring regulatory relationships among many genes based on their temporal variation in transcript abundance has been a popular research topic. Due to the nature of microarray experiments, classical tools for time series analysis lose power since the ...
Li Chang-Tsun, Yuan Yinyin, Yuan, Yinyin, Windram Oliver, Chang-Tsun Li, Windram, Oliver P., Oliver Windram, Yinyin Yuan, Li, Chang-Tsun   +8 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

De novo evolution of complex, global and hierarchical gene regulatory mechanisms [PDF]

, 2010
Gene regulatory networks exhibit complex, hierarchical features such as global regulation and network motifs. There is much debate about whether the evolutionary origins of such features are the results of adaptation, or the by-products of non-adaptive ...
Dov J. Stekel, Jenkins, Dafyd J., Dafyd J. Jenkins, Stekel, Dov   +3 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Toward an orofacial gene regulatory network [PDF]

Developmental Dynamics, 2015
Orofacial clefting is a common birth defect with significant morbidity. A panoply of candidate genes have been discovered through synergy of animal models and human genetics. Among these, variants in interferon regulatory factor 6 (IRF6) cause syndromic orofacial clefting and contribute risk toward isolated cleft lip and palate (1/700 live births ...
Youssef A, Kousa, Brian C, Schutte
openaire   +2 more sources