Results 51 to 60 of about 474,387 (314)
Regulatory network operations in the Pathway Tools software
BMC Bioinformatics, 2012 Background Biologists are elucidating complex collections of genetic regulatory data for multiple organisms. Software is needed for such regulatory network data.
Paley Suzanne M +2 more
doaj +1 more source
Efficient reverse-engineering of a developmental gene regulatory network. [PDF]
PLoS Computational Biology, 2012 Understanding the complex regulatory networks underlying development and evolution of multi-cellular organisms is a major problem in biology. Computational models can be used as tools to extract the regulatory structure and dynamics of such networks from
Anton Crombach +4 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Filtering for nonlinear genetic regulatory networks with stochastic disturbances [PDF]
, 2008 In this paper, the filtering problem is investigated for nonlinear genetic regulatory networks with stochastic disturbances and time delays, where the nonlinear function describing the feedback regulation is assumed to satisfy the sector condition, the ...
Liu, X +4 more
core +1 more source
Research on Controllability of Gene Regulatory Network Based on Longest Control Chain [PDF]
Jisuanji gongcheng, 2018 In order to analyze the controllability of gene regulation network,in this paper,the gene regulatory network in human cell cycle is studied,and the structural control process of gene network is reconstructed based on the Boolean logic functions,which are
BAI Xueyi,GUO Binghui,LI Jiahui,ZHENG Zhiming
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Sea Urchin Regulome in Development [PDF]
, 2007 During development an organism undergoes many rounds of pattern formation, generating ever greater complexity with each ensuing round of cell division and specification.
Ashby, Meredith Howard
core +1 more source
Metabolic constraint-based refinement of transcriptional regulatory networks. [PDF]
PLoS Computational Biology, 2013 There is a strong need for computational frameworks that integrate different biological processes and data-types to unravel cellular regulation. Current efforts to reconstruct transcriptional regulatory networks (TRNs) focus primarily on proximal data ...
Sriram Chandrasekaran, Nathan D Price
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hopf bifurcation in a gene regulatory network model : molecular movement causes oscillations [PDF]
, 2014 M.A.J.C. and M.S. gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, “M5CGS — From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread”. M.S.
Ptashnyk, Mariya +10 more
core +1 more source