Results 31 to 40 of about 789,865 (294)
Fan-out in gene regulatory networks [PDF]
Journal of Biological Engineering, 2010 In synthetic biology, gene regulatory circuits are often constructed by combining smaller circuit components. Connections between components are achieved by transcription factors acting on promoters. If the individual components behave as true modules and certain module interface conditions are satisfied, the function of the composite circuits can in ...
Sauro Herbert M, Kim Kyung H
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Time-delayed models of gene regulatory networks [PDF]
, 2015 We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time ...
Blyuss, K B +3 more
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Dynamical Criticality in Gene Regulatory Networks [PDF]
Complexity, 2018 A well‐known hypothesis, with far‐reaching implications, is that biological evolution should preferentially lead to states that are dynamically critical. In previous papers, we showed that a well‐known model of genetic regulatory networks, namely, that of random Boolean networks, allows one to study in depth the relationship between the dynamical ...
Villani, Marco +3 more
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Gene autoregulation via intronic microRNAs and its functions [PDF]
, 2012 Background: MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad range of human diseases.
Baroudi, Mariama El +4 more
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GeRNet: a gene regulatory network tool [PDF]
Biosystems, 2017 Gene regulatory networks (GRNs) are crucial in every process of life since they govern the majority of the molecular processes. Therefore, the task of assembling these networks is highly important. In particular, the so called model-free approaches have an advantage modeling the complexities of dynamic molecular networks, since most of the gene ...
Julieta Sol Dussaut +5 more
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Approximate kernel reconstruction for time-varying networks
BioData Mining, 2019 Background Most existing algorithms for modeling and analyzing molecular networks assume a static or time-invariant network topology. Such view, however, does not render the temporal evolution of the underlying biological process as molecular networks ...
Gregory Ditzler +3 more
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Stochastic neural network models for gene regulatory networks [PDF]
, 2003 Recent advances in gene-expression profiling technologies provide large amounts of gene expression data. This raises the possibility for a functional understanding of genome dynamics by means of mathematical modelling.
Burrage, K., Tian, T.
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Understanding Tissue-Specific Gene Regulation
Cell Reports, 2017 Summary: Although all human tissues carry out common processes, tissues are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity.
Abhijeet Rajendra Sonawane +9 more
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Variable levels of drift in tunicate cardiopharyngeal gene regulatory elements
EvoDevo, 2019 Background Mutations in gene regulatory networks often lead to genetic divergence without impacting gene expression or developmental patterning. The rules governing this process of developmental systems drift, including the variable impact of selective ...
William Colgan +25 more
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Literature-based priors for gene regulatory networks [PDF]
, 2009 Motivation: The use of prior knowledge to improve gene regulatory network modelling has often been proposed. In this paper we present the first research on the massive incorporation of prior knowledge from literature for Bayesian network learning of gene
't Hoen, PAC +3 more
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