Results 21 to 30 of about 474,387 (314)

Reduction of the chemical master equation for gene regulatory networks using proper generalized decompositions [PDF]

, 2012
The numerical solution of the chemical master equation (CME) governing gene regulatory networks and cell signaling processes remains a challenging task owing to its complexity, exponentially growing with the number of species involved.
CHINESTA SORIA, Francisco, Chinesta, Francisco, CUETO, Elias, AMMAR, Amine   +3 more
core   +1 more source

Reconstruction of gene regulatory modules in cancer cell cycle by multi-source data integration. [PDF]

PLoS ONE, 2010
Precise regulation of the cell cycle is crucial to the growth and development of all organisms. Understanding the regulatory mechanism of the cell cycle is crucial to unraveling many complicated diseases, most notably cancer.
Yuji Zhang, Jianhua Xuan, Benildo G de los Reyes, Robert Clarke, Habtom W Ressom   +4 more
doaj   +1 more source

A method to construct gene regulatory networks to estimate and calculate time delays [PDF]

, 2013
In general, the motive of this research is to infer gene regulatory network in order to clarify the basis consequences of biological process at the molecular level.
Mohamad, Mohd. Saberi, Chai, Suk Phin
core   +1 more source

Comprehensive information-based differential gene regulatory networks analysis (CIdrgn): Application to gastric cancer and chemotherapy-responsive gene network identification.

PLoS ONE, 2023
Biological condition-responsive gene network analysis has attracted considerable research attention because of its ability to identify pathways or gene modules involved in the underlying mechanisms of diseases.
Heewon Park, Seiya Imoto, Satoru Miyano
doaj   +2 more sources

Wheat leaf senescence and its regulatory gene network

Crop Journal, 2021
Wheat leaf senescence is a developmental process that involves expressional changes in thousands of genes that ultimately impact grain protein content (GPC), grain yield (GY), and nitrogen use efficiency.
Nigarin Sultana, Shahidul Islam, Angela Juhasz, Wujun Ma   +3 more
doaj   +1 more source

Correlated fluctuations carry signatures of gene regulatory network dynamics [PDF]

, 2010
The dynamics of transcriptional control involve small numbers of molecules and result in significant fluctuations in protein and mRNA concentrations.
Pakka, V. H., Pakka, Vijayanarasimha H., Prugel-Bennett, Adam, Prugel-Bennett, A., Adam Prügel-Bennett, Dasmahapatra, S., Pakka, Vijayanarasimha, Dasmahapatra, Srinandan, Vijayanarasimha H. Pakka, Srinandan Dasmahapatra   +9 more
core   +1 more source

Single-cell transcriptomics unveils gene regulatory network plasticity

Genome Biology, 2019
Background Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our understanding of cellular heterogeneity. Current analytical workflows are driven by categorizing principles that consider cells as individual entities and classify them into ...
Giovanni Iacono, Ramon Massoni-Badosa, Holger Heyn   +2 more
doaj   +1 more source

A boolean model of the cardiac gene regulatory network determining first and second heart field identity. [PDF]

PLoS ONE, 2012
Two types of distinct cardiac progenitor cell populations can be identified during early heart development: the first heart field (FHF) and second heart field (SHF) lineage that later form the mature heart.
Franziska Herrmann, Alexander Groß, Dao Zhou, Hans A Kestler, Michael Kühl   +4 more
doaj   +1 more source

Integrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer Metastasis

Cancer Informatics, 2014
Integrative analysis of multi-level molecular profiles can distinguish interactions that cannot be revealed based on one kind of data in the analysis of cancer susceptibility and metastasis.
Seyed M. Iranmanesh, Nancy L. Guo
doaj   +2 more sources

Gene regulatory network reconfiguration in direct lineage reprogramming

Stem Cell Reports, 2023
Summary: In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity.
Kenji Kamimoto, Mohd Tayyab Adil, Kunal Jindal, Christy M. Hoffmann, Wenjun Kong, Xue Yang, Samantha A. Morris   +6 more
doaj   +1 more source