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Frontiers in Bioinformatics, 2022 Brain tumor research has been stapled for human health while brain network research is crucial for us to understand brain activity. Here the structural controllability theory is applied to study three human brain-specific gene regulatory networks ...
Zhihua Chen, Siyuan Chen, Xiaoli Qiang
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Artificial Gene Regulatory Networks—A Review [PDF]
Artificial Life, 2019 In nature, gene regulatory networks are a key mediator between the information stored in the DNA of living organisms (their genotype) and the structural and behavioral expression this finds in their bodies, surviving in the world (their phenotype). They integrate environmental signals, steer development, buffer stochasticity, and allow evolution to ...
Cussat-Blanc, Sylvain +2 more
openaire +4 more sources
Stochastic models and numerical algorithms for a class of regulatory gene networks [PDF]
, 2008 Regulatory gene networks contain generic modules like those involving feedback loops, which are essential for the regulation of many biological functions.
Fournier, Thomas +5 more
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Wheat leaf senescence and its regulatory gene network
Crop Journal, 2021 Wheat leaf senescence is a developmental process that involves expressional changes in thousands of genes that ultimately impact grain protein content (GPC), grain yield (GY), and nitrogen use efficiency.
Nigarin Sultana +3 more
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A boolean model of the cardiac gene regulatory network determining first and second heart field identity. [PDF]
PLoS ONE, 2012 Two types of distinct cardiac progenitor cell populations can be identified during early heart development: the first heart field (FHF) and second heart field (SHF) lineage that later form the mature heart.
Franziska Herrmann +4 more
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Emergent adaptive behaviour of GRN-controlled simulated robots in a changing environment [PDF]
, 2016 We developed a bio-inspired robot controller combining an artificial genome with an agent-based control system. The genome encodes a gene regulatory network (GRN) that is switched on by environmental cues and, following the rules of transcriptional ...
Marchal, Kathleen +3 more
core +4 more sources
Current approaches to gene regulatory network modelling
BMC Bioinformatics, 2007 Many different approaches have been developed to model and simulate gene regulatory networks. We proposed the following categories for gene regulatory network models: network parts lists, network topology models, network control logic models, and dynamic
Brazma Alvis, Schlitt Thomas
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Single-cell transcriptomics unveils gene regulatory network plasticity
Genome Biology, 2019 Background Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our understanding of cellular heterogeneity. Current analytical workflows are driven by categorizing principles that consider cells as individual entities and classify them into ...
Giovanni Iacono +2 more
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Gene regulatory network reconfiguration in direct lineage reprogramming
Stem Cell Reports, 2023 Summary: In direct lineage conversion, transcription factor (TF) overexpression reconfigures gene regulatory networks (GRNs) to reprogram cell identity.
Kenji Kamimoto +6 more
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Gene regulatory networks that control the specification of neural-crest cells in the lamprey [PDF]
, 2009 The lamprey is the only basal vertebrate in which large-scale gene perturbation analyses are feasible at present. Studies on this unique animal model promise to contribute both to the understanding of the basic neural-crest gene regulatory network ...
Bronner-Fraser, Marianne +1 more
core +1 more source