Results 41 to 50 of about 789,865 (294)

Gene Regulatory Networks in the Genomics Era

Genomics, Proteomics & Bioinformatics, 2013
The precise regulation of gene expression is critical to the normal development and biological function of all organisms. Dysregulation of gene expression during early development can result in a spectrum of failures ranging from minor defects to the termination of development.
Matthew Loose, Roger Patient, Xiangdong Fang, Hongxing Lei   +3 more
openaire   +4 more sources

Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo [PDF]

, 2008
We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm.
Alifragis, Davidson, Dawson, E. H. Davidson, Fisher, Giagtzoglou, Gyory, Howard-Ashby, Howard-Ashby, J. Smith, Kuo, Lee, Livi, Materna, McClay, Minokawa, Oellers, Oliveri, Osipovich, Peterson, Ransick, Revilla-i-Domingo, Rizzo, Robertson, Sea Urchin Genome Sequencing Consortium, Sherwood, Smith, Smith, Thirunavukkarasu, Tietze, Tu, Walton, Wikramanayake, Yu, Yuh   +34 more
core   +3 more sources

Model Checking Gene Regulatory Networks [PDF]

, 2015
19 pages, 20 references, 4 ...
Mirco Giacobbe, Calin C. Guet, Ashutosh Gupta 0001, Thomas A. Henzinger, Tiago Paixão, Tatjana Petrov   +5 more
openaire   +3 more sources

Dynamic Bayesian networks in molecular plant science: inferring gene regulatory networks from multiple gene expression time series [PDF]

, 2011
To understand the processes of growth and biomass production in plants, we ultimately need to elucidate the structure of the underlying regulatory networks at the molecular level.
Dondelinger, F., Husmeier, D., Lebre, S.
core   +3 more sources

Evolution of Evolvability in Gene Regulatory Networks

PLoS Computational Biology, 2008
Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes. For the last decade, the study of such networks has been fueled by large-scale experiments and renewed attention from the theoretical field.
Anton Crombach, Paulien Hogeweg
openaire   +5 more sources

A novel mutual information-based Boolean network inference method from time-series gene expression data.

PLoS ONE, 2017
BackgroundInferring a gene regulatory network from time-series gene expression data in systems biology is a challenging problem. Many methods have been suggested, most of which have a scalability limitation due to the combinatorial cost of searching a ...
Shohag Barman, Yung-Keun Kwon
doaj   +1 more source

Efficient reverse-engineering of a developmental gene regulatory network. [PDF]

PLoS Computational Biology, 2012
Understanding the complex regulatory networks underlying development and evolution of multi-cellular organisms is a major problem in biology. Computational models can be used as tools to extract the regulatory structure and dynamics of such networks from
Anton Crombach, Karl R Wotton, Damjan Cicin-Sain, Maksat Ashyraliyev, Johannes Jaeger   +4 more
doaj   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Homeostasis in gene regulatory networks

International Journal of Biomathematics
Gene regulatory networks lie at the heart of many important intracellular signal transduction processes. A Gene Regulatory Network (GRN) is abstractly defined as a directed graph, where the nodes represent genes and the edges represent the causal regulatory interactions between genes. It can be used to construct mathematical models describing the time-
Fernando Antoneli, Martin Golubitsky, Jiaxin Jin, Ian Stewart   +3 more
openaire   +2 more sources

Regulatory network operations in the Pathway Tools software

BMC Bioinformatics, 2012
Background Biologists are elucidating complex collections of genetic regulatory data for multiple organisms. Software is needed for such regulatory network data.
Paley Suzanne M, Latendresse Mario, Karp Peter D   +2 more
doaj   +1 more source