Results 41 to 50 of about 8,545,689 (298)
Efficient reverse-engineering of a developmental gene regulatory network. [PDF]
PLoS Computational Biology, 2012 Understanding the complex regulatory networks underlying development and evolution of multi-cellular organisms is a major problem in biology. Computational models can be used as tools to extract the regulatory structure and dynamics of such networks from
Anton Crombach +4 more
doaj +1 more source
Homeostasis in gene regulatory networks
International Journal of BiomathematicsGene regulatory networks lie at the heart of many important intracellular signal transduction processes. A Gene Regulatory Network (GRN) is abstractly defined as a directed graph, where the nodes represent genes and the edges represent the causal regulatory interactions between genes. It can be used to construct mathematical models describing the time-
Fernando Antoneli +3 more
openaire +2 more sources
Evolution of Evolvability in Gene Regulatory Networks
PLoS Computational Biology, 2008 Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes. For the last decade, the study of such networks has been fueled by large-scale experiments and renewed attention from the theoretical field.
Anton Crombach, Paulien Hogeweg
openaire +6 more sources
Modelling nonstationary gene regulatory processes [PDF]
, 2010 An important objective in systems biology is to infer gene regulatory networks from postgenomic data, and dynamic Bayesian networks have been widely applied as a popular tool to this end.
Husmeier, D. +5 more
core +1 more source
PLoS ONE, 2017 BackgroundInferring a gene regulatory network from time-series gene expression data in systems biology is a challenging problem. Many methods have been suggested, most of which have a scalability limitation due to the combinatorial cost of searching a ...
Shohag Barman, Yung-Keun Kwon
doaj +1 more source
Mean field analysis of a spatial stochastic model of a gene regulatory network [PDF]
, 2015 A gene regulatory network may be defined as a collection of DNA segments which interact with each other indirectly through their RNA and protein products.
Murray, P. J. +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
On Hybrid Gene Regulatory Networks
CoRRIn this work, we study a class of hybrid dynamical systems called hybrid gene regulatory networks (HGRNs) which was proposed to model gene regulatory networks. In HGRNs, there exist well-behaved trajectories that reach a fixed point or converge to a limit cycle, as well as chaotic trajectories that behave non-periodic or indeterministic.
Adrian Wurm, Honglu Sun
openaire +3 more sources
Regulatory network operations in the Pathway Tools software
BMC Bioinformatics, 2012 Background Biologists are elucidating complex collections of genetic regulatory data for multiple organisms. Software is needed for such regulatory network data.
Paley Suzanne M +2 more
doaj +1 more source