Results 81 to 90 of about 474,387 (314)

Towards more biological mutation operators in gene regulation studies [PDF]

, 2003
Genetic regulation is often viewed as a complex system whose properties emerge from the interaction of regulatory genes. One major paradigm for studying the complex dynamics of gene regulation uses directed graphs to explore structure, behaviour and ...
Wiles, J., Nicholas Geard, Watson, J., Geard, N, Wiles, Janet, Watson, James, Janet Wiles, Wiles, J, Watson, J, James Watson, Geard, N.L., Geard, Nicholas   +11 more
core   +1 more source

Tightly regulated expression of Autographa californica multicapsid nucleopolyhedrovirus immediate early genes emerges from their interactions and possible collective behaviors. [PDF]

PLoS ONE, 2015
To infect their hosts, DNA viruses must successfully initiate the expression of viral genes that control subsequent viral gene expression and manipulate the host environment.
Chikako Ono, Masanao Sato, Hitomi Taka, Shin-ichiro Asano, Yoshiharu Matsuura, Hisanori Bando   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

HGATLink: single-cell gene regulatory network inference via the fusion of heterogeneous graph attention networks and transformer

BMC Bioinformatics
Background Gene regulatory networks (GRNs) involve complex regulatory relationships between genes and play important roles in the study of various biological systems and diseases.
Yao Sun, Jing Gao
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Planning for Gene Regulatory Network Intervention [PDF]

2006 IEEE/NLM Life Science Systems and Applications Workshop, 2006
Modeling the dynamics of cellular processes has recently become a important research area of many disciplines. One of the most important reasons to model a cellular process is to enable high-throughput in-silico experiments that attempt to predict or intervene in the process.
Daniel Bryce, Seungchan Kim
openaire   +2 more sources

A Study of Information Processing in the Sea Urchin Embryo by Rewiring Mesodermal Gene Regulatory Networks and cis-Regulatory Analysis of Skeletogenic Regulators [PDF]

, 2011
This work focuses on the GRNs specifying embryonic skeletogenesis and the pigment cell differentiation in the purple sea urchin, Strongylocentrotus purpuratus.
Damle, Sagar S.
core   +1 more source

Estimating Gene Regulatory Activity using Mathematical Optimization [PDF]

, 2020
Die Regulation der Genexpression ist einer der wichtigsten zellulären Prozesse und steht in Zusammenhang mit der Entstehung diverser Krankheiten. Regulationsmechanismen können mit einer Vielzahl von Methoden experimentell untersucht werden, zugleich ...
Trescher, Saskia
core   +1 more source

Reconstruct gene regulatory network using slice pattern model

BMC Genomics, 2009
Background Gene expression time series array data has become a useful resource for investigating gene functions and the interactions between genes.
Yang Bo, Wang Guohua, Wang Yadong, Tao Haijun, Yang Jack Y, Deng Youping, Liu Yunlong   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source