Results 101 to 110 of about 5,034,704 (247)

Genetic properties underlying transcriptional variability across different perturbations

Nature Communications
The rate and direction of phenotypic evolution depend on the availability of phenotypic variants induced genetically or environmentally. It is widely accepted that organisms do not display uniform phenotypic variation, with certain variants arising more ...
Saburo Tsuru, Chikara Furusawa
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks

, 2017
Here, we present the updated rSNPBase 3.0 database (http://rsnp3.psych.ac.cn), which provides human SNP-related regulatory elements, element-gene pairs and SNP-based regulatory networks.
Jing Wang, Liyuan Guo, Guo, Liyuan, Wang, Jing   +3 more
core   +1 more source

Activity of microRNAs and transcription factors in Gene Regulatory Networks [PDF]

, 2012
In biological research, diverse high-throughput techniques enable the investigation of whole systems at the molecular level. The development of new methods and algorithms is necessary to analyze and interpret measurements of gene and protein expression ...
Naeem, Haroon
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Using large-scale perturbations in gene network reconstruction [PDF]

, 2005
Background: Recent analysis of the yeast gene network shows that most genes have few inputs, indicating that enumerative gene reconstruction methods are both useful and computationally feasible.
Andrew Pomiankowski, MacCarthy, T, Pomiankowski Andrew, Robert Seymour, Seymour Robert, Pomiankowski, A, Thomas MacCarthy, Seymour, R, MacCarthy Thomas   +8 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Interspecies Translation of Disease Networks Increases Robustness and Predictive Accuracy [PDF]

, 2011
© 2011 Anvar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Seyed Yahya Anvar, Gert-Jan B. van Ommen, Raz, V., Vered Raz, Raz, V, Ommen, G.J.B. van, Tucker, A., Tucker, A, Allan Tucker, Silvere M van der Maarel, Anvar, S.Y., van der Maarel, SM, Veronica Vinciotti, Andrea Venema, Silvere M. van der Maarel, Hoen, P.A.C. 't, Vinciotti, V., Peter A C 't Hoen, van Ommen, G-JB, Maarel, S.M. van der, Vinciotti, V, Venema, A, Anvar, SY, Venema, A., Peter A. C. ‘t Hoen, Gert-Jan B van Ommen, 't Hoen, PAC   +26 more
core   +2 more sources

Dynamical approaches to modeling developmental gene regulatory networks

The network of interacting regulatory signals within a cell comprises one of the most complex and powerful computational systems in biology. Gene regulatory networks play a key role in transforming the information encoded in a genome into morphological ...
Geard, Nicholas, Willadsen, Kai
core   +1 more source

Reconstructing Dynamic Gene Regulatory Networks Using f-Divergence from Time-Series scRNA-Seq Data

Current Issues in Molecular Biology
Inferring time-varying gene regulatory networks from time-series single-cell RNA sequencing (scRNA-seq) data remains a challenging task. The existing methods have notable limitations as most are either designed for reconstructing time-varying networks ...
Yunge Wang, Lingling Zhang, Tong Si, Sarah Roberts, Yuqi Wang, Haijun Gong   +5 more
doaj   +1 more source