Results 101 to 110 of about 946,920 (339)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Constructing tissue-specific transcriptional regulatory networks via a Markov random field

BMC Genomics, 2018
Background Recent advances in sequencing technologies have enabled parallel assays of chromatin accessibility and gene expression for major human cell lines.
Shining Ma, Tao Jiang, Rui Jiang
doaj   +1 more source

Planning for Gene Regulatory Network Intervention [PDF]

2006 IEEE/NLM Life Science Systems and Applications Workshop, 2006
Modeling the dynamics of cellular processes has recently become a important research area of many disciplines. One of the most important reasons to model a cellular process is to enable high-throughput in-silico experiments that attempt to predict or intervene in the process.
Daniel Bryce, Seungchan Kim
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ViBEx: A Visualization Tool for Gene Expression Analysis

BioMedInformatics
Background: Variations in the states of Gene Regulatory Networks significantly influence disease outcomes and drug development. Boolean Networks serve as a tool to conceptualize and understand the complex relationships between genes.
Michael H. Terrefortes-Rosado, Andrea V. Nieves-Rivera, Humberto Ortiz-Zuazaga, Marie Lluberes-Contreras   +3 more
doaj   +1 more source

Approximate kernel reconstruction for time-varying networks

BioData Mining, 2019
Background Most existing algorithms for modeling and analyzing molecular networks assume a static or time-invariant network topology. Such view, however, does not render the temporal evolution of the underlying biological process as molecular networks ...
Gregory Ditzler, Nidhal Bouaynaya, Roman Shterenberg, Hassan M. Fathallah-Shaykh   +3 more
doaj   +1 more source

Modeling regulatory network topology improves genome-wide analyses of complex human traits

Nature Communications, 2021
Gene regulatory networks are a useful means of inferring functional interactions from large-scale genomic data. Here, the authors develop a Bayesian framework integrating GWAS summary statistics with gene regulatory networks to identify genetic ...
Xiang Zhu, Zhana Duren, Wing Hung Wong
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Inference of Gene Regulatory Networks for Overcoming Low Performance in Real-World Data

IEEE Access
The identification of gene regulatory networks is important for understanding the mechanisms of various biological phenomena. Many methods have been proposed to infer networks from time-series gene expression data obtained by high-throughput next ...
Yusuke Hiki, Yuta Tokuoka, Takahiro G. Yamada, Akira Funahashi   +3 more
doaj   +1 more source