Results 81 to 90 of about 509,029 (282)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ViBEx: A Visualization Tool for Gene Expression Analysis

BioMedInformatics
Background: Variations in the states of Gene Regulatory Networks significantly influence disease outcomes and drug development. Boolean Networks serve as a tool to conceptualize and understand the complex relationships between genes.
Michael H. Terrefortes-Rosado, Andrea V. Nieves-Rivera, Humberto Ortiz-Zuazaga, Marie Lluberes-Contreras   +3 more
doaj   +1 more source

Constructing tissue-specific transcriptional regulatory networks via a Markov random field

BMC Genomics, 2018
Background Recent advances in sequencing technologies have enabled parallel assays of chromatin accessibility and gene expression for major human cell lines.
Shining Ma, Tao Jiang, Rui Jiang
doaj   +1 more source

Inherent size constraints on prokaryote gene networks due to "accelerating" growth

, 2004
Networks exhibiting "accelerating" growth have total link numbers growing faster than linearly with network size and can exhibit transitions from stationary to nonstationary statistics and from random to scale-free to regular statistics at particular ...
Gagen, M. J., Mattick, J. S.
core   +1 more source

Planning for Gene Regulatory Network Intervention [PDF]

2006 IEEE/NLM Life Science Systems and Applications Workshop, 2006
Modeling the dynamics of cellular processes has recently become a important research area of many disciplines. One of the most important reasons to model a cellular process is to enable high-throughput in-silico experiments that attempt to predict or intervene in the process.
Daniel Bryce, Seungchan Kim
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Modeling regulatory network topology improves genome-wide analyses of complex human traits

Nature Communications, 2021
Gene regulatory networks are a useful means of inferring functional interactions from large-scale genomic data. Here, the authors develop a Bayesian framework integrating GWAS summary statistics with gene regulatory networks to identify genetic ...
Xiang Zhu, Zhana Duren, Wing Hung Wong
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Approximate kernel reconstruction for time-varying networks

BioData Mining, 2019
Background Most existing algorithms for modeling and analyzing molecular networks assume a static or time-invariant network topology. Such view, however, does not render the temporal evolution of the underlying biological process as molecular networks ...
Gregory Ditzler, Nidhal Bouaynaya, Roman Shterenberg, Hassan M. Fathallah-Shaykh   +3 more
doaj   +1 more source

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

Nature Communications, 2021
The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to ...
Benxia Hu, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A. Crowley, Sirisha Pochareddy, The PsychENCODE Consortium, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H. Geschwind   +14 more
doaj   +1 more source