Results 61 to 70 of about 946,920 (339)

Model Checking Gene Regulatory Networks [PDF]

, 2015
19 pages, 20 references, 4 ...
Mirco Giacobbe, Calin C. Guet, Ashutosh Gupta 0001, Thomas A. Henzinger, Tiago Paixão, Tatjana Petrov   +5 more
openaire   +3 more sources

Petri Nets with Fuzzy Logic (PNFL): Reverse Engineering and Parametrization [PDF]

, 2010
Background: The recent DREAM4 blind assessment provided a particularly realistic and challenging setting for network reverse engineering methods.
Küffner, Robert, Ralf Zimmer, Lukas Windhager, Robert Küffner, Petri, Tobias, Küffner Robert, Windhager, Lukas, Tobias Petri, Windhager Lukas, Zimmer, Ralf, Zimmer Ralf, Petri Tobias   +11 more
core   +1 more source

Gene Regulatory Networks in the Genomics Era

Genomics, Proteomics & Bioinformatics, 2013
The precise regulation of gene expression is critical to the normal development and biological function of all organisms. Dysregulation of gene expression during early development can result in a spectrum of failures ranging from minor defects to the termination of development.
Matthew Loose, Roger Patient, Xiangdong Fang, Hongxing Lei   +3 more
openaire   +4 more sources

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Nature Communications
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes in cell identity by affecting gene expression.
Fjodor Merkuri, M. Rothstein, Marcos Simoes-Costa   +2 more
semanticscholar   +1 more source

Determining the Properties of Gene Regulatory Networks from Expression Data

, 2009
Recent advances in gene sequencing technology are now shedding light on the complex interplay between genes that elicit phenotypic behavior characteristic of any given organism.
Shehadeh, Lina, Das, Sanjoy, Caragea, Doina, Welch, Stephen, Hsu, William H   +4 more
core   +1 more source

Emergence of co-expression in gene regulatory networks.

PLoS ONE, 2021
Transcriptomes are known to organize themselves into gene co-expression clusters or modules where groups of genes display distinct patterns of coordinated or synchronous expression across independent biological samples.
Wencheng Yin, Luis Mendoza, Jimena Monzon-Sandoval, Araxi O Urrutia, Humberto Gutierrez   +4 more
doaj   +1 more source

Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation

Nature Cell Biology
In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear whether this spatial variation, called zonation, is governed by a well-defined gene regulatory ...
C. Bravo González-Blas, Irina Matetovici, H. Hillen, I. I. Taskiran, Roel Vandepoel, Valerie Christiaens, L. Sansores-García, E. Verboven, Gert J. Hulselmans, S. Poovathingal, J. Demeulemeester, Nikoleta Psatha, D. Mauduit, Georg Halder, S. Aerts   +14 more
semanticscholar   +1 more source

Regulation and dysregulation of microRNA - transcription factor axes in differentiation and neuroblastoma

Cellular and Molecular Life Sciences
Development is characterized by dynamic changes in gene expression as cells traverse genetic pathways and make lineage-specific commitments. Transcription factors, which drive gene expression, and microRNAs, the largest class of post-transcriptional ...
Fakhira H. Nazki, Cameron P. Bracken
doaj   +1 more source

Predicting gene regulatory networks from cell atlases

Life Science Alliance, 2020
Integrated single-cell gene regulatory network from three mouse cell atlases captures global and cell type–specific regulatory modules and crosstalk, important for cellular identity.
Andreas Fønss Møller, Kedar Nath Natarajan   +1 more
doaj   +1 more source

Dynamical methods for target control of biological networks

Royal Society Open Science, 2023
Estimating the influence that individual nodes have on one another in a Boolean network is essential to predict and control the system’s dynamical behaviour, for example, detecting key therapeutic targets to control pathways in models of biological ...
Thomas Parmer, Filippo Radicchi
doaj   +1 more source