Results 71 to 80 of about 946,920 (339)

Homeostasis in gene regulatory networks

International Journal of Biomathematics
Gene regulatory networks lie at the heart of many important intracellular signal transduction processes. A Gene Regulatory Network (GRN) is abstractly defined as a directed graph, where the nodes represent genes and the edges represent the causal regulatory interactions between genes. It can be used to construct mathematical models describing the time-
Fernando Antoneli, Martin Golubitsky, Jiaxin Jin, Ian Stewart   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities

BMC Bioinformatics, 2011
Background Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes.
Dickerson Julie A, Jarboe Laura R, Fu Yao   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Integration of probabilistic regulatory networks into constraint-based models of metabolism with applications to Alzheimer’s disease

BMC Bioinformatics, 2019
Background Mathematical models of biological networks can provide important predictions and insights into complex disease. Constraint-based models of cellular metabolism and probabilistic models of gene regulatory networks are two distinct areas that ...
Han Yu, Rachael Hageman Blair
doaj   +1 more source

Evaluating methods of inferring gene regulatory networks highlights their lack of performance for single cell gene expression data

BMC Bioinformatics, 2018
A fundamental fact in biology states that genes do not operate in isolation, and yet, methods that infer regulatory networks for single cell gene expression data have been slow to emerge.
Shuonan Chen, J. Mar
semanticscholar   +1 more source

Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms

, 2009
Baumbach J, Rahmann S, Tauch A. Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms. BMC Systems Biology.
Sven Rahmann, Andreas Tauch, Tauch, Andreas, Baumbach, Jan, Jan Baumbach, Rahmann, Sven   +5 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

CoryneRegNet 4.0 – A reference database for corynebacterial gene regulatory networks

BMC Bioinformatics, 2007
Background Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression) and on transcriptional regulatory interactions of microorganisms deduced from literature-derived knowledge, computer predictions ...
Baumbach Jan
doaj   +1 more source

XGRN: Reconstruction of Biological Networks Based on Boosted Trees Regression

Computation, 2021
In Systems Biology, the complex relationships between different entities in the cells are modeled and analyzed using networks. Towards this aim, a rich variety of gene regulatory network (GRN) inference algorithms has been developed in recent years ...
Georgios N. Dimitrakopoulos
doaj   +1 more source