Results 91 to 100 of about 946,920 (339)
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks
Development, 2019 During development, gene regulatory networks allocate cell fates by partitioning tissues into spatially organised domains of gene expression. How the sharp boundaries that delineate these gene expression patterns arise, despite the stochasticity ...
Katherine Exelby +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Global gene network exploration based on explainable artificial intelligence approach.
PLoS ONE, 2020 In recent years, personalized gene regulatory networks have received significant attention, and interpretation of the multilayer networks has been a critical issue for a comprehensive understanding of gene regulatory systems. Although several statistical
Heewon Park +4 more
doaj +1 more source
Signaling and gene regulatory networks in mammalian lens development
Trends in Genetics, 2017 Ocular lens development represents an advantageous system to study regulatory mechanisms governing cell fate decisions, extracellular signaling, cell and tissue organization, and underlying gene regulatory networks.
A. Cvekl, Xin Zhang
semanticscholar +1 more source
Deconstructing the pluripotency gene regulatory network [PDF]
Nature Cell Biology, 2018 Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-
Mo Li, Juan Carlos Izpisua Belmonte
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Using temporal correlation in factor analysis for reconstructing transcription factor activities
, 2008 Two-level gene regulatory networks consist of the transcription factors (TFs) in the top level and their regulated genes in the second level. The expression profiles of the regulated genes are the observed high-throughput data given by experiments such ...
Wernisch, Lorenz +3 more
core +1 more source
, 2020 These are the processed datasets used to create networks (raw and filtered expression tables) and predicted interactionsRegulation of gene expression is central to many biological processes. Gene regulatory networks (GRNs) link transcription factors (TFs)
Springer, Nathan M., Zhou, Peng
core +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Enhanced construction of gene regulatory networks using hub gene information
BMC Bioinformatics, 2017 Gene regulatory networks reveal how genes work together to carry out their biological functions. Reconstructions of gene networks from gene expression data greatly facilitate our understanding of underlying biological mechanisms and provide new ...
Donghyeon Yu +4 more
semanticscholar +1 more source