Results 31 to 40 of about 649,536 (308)

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. [PDF]

, 2014
With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardiac disease therapies.
Benner, Christopher, Crespo, Isaac, Del Sol, Antonio, Esteban, Concepcion Rodriguez, Gu, Ying, Izpisua Belmonte, Juan Carlos, Li, Mo, Liu, Guang-Hui, Montserrat, Nuria, Plongthongkum, Nongluk, Qu, Jing, Suzuki, Keiichiro, Yang, Jiping, Yi, Fei, Zhang, Kun, Zhang, Weiqi   +15 more
core   +3 more sources

A comparison of curated gene sets versus transcriptomics-derived gene signatures for detecting pathway activation in immune cells

BMC Bioinformatics, 2020
Background Despite the significant contribution of transcriptomics to the fields of biological and biomedical research, interpreting long lists of significantly differentially expressed genes remains a challenging step in the analysis process.
Bin Liu, Patrick Lindner, Adan Chari Jirmo, Ulrich Maus, Thomas Illig, David S. DeLuca   +5 more
doaj   +1 more source

Systematic establishment and verification of an epithelial-mesenchymal transition gene signature for predicting prognosis of oral squamous cell carcinoma

Frontiers in Genetics, 2023
Objective: Epithelial-mesenchymal transition (EMT) is linked to an unfavorable prognosis in oral squamous cell carcinoma (OSCC). Here, we aimed to develop an EMT gene signature for OSCC prognosis.Methods: In TCGA dataset, prognosis-related EMT genes with
Jun Ai, Yaqin Tan, Bo Liu, Yuhong Song, Yanqin Wang, Xin Xia, Qicheng Fu   +6 more
doaj   +1 more source

Super-paramagnetic clustering of yeast gene expression profiles [PDF]

, 1999
High-density DNA arrays, used to monitor gene expression at a genomic scale, have produced vast amounts of information which require the development of efficient computational methods to analyze them.
Alon, Blatt, Blatt, De Risi, Domany, E. Domany, E. Levine, Eisen, G. Getz, Hartigan, Koch, Kohonen, Lascaris, Li, Lockhart, M.Q. Zhang, Mager, Spellman, Tamayo, Zhang, Zhang, Zhu   +21 more
core   +6 more sources

A simple and robust method for connecting small-molecule drugs using gene-expression signatures [PDF]

, 2008
Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar ...
B Efron, CC Ting, J Frasor, J Lamb, JD Storey, JJ Chen, JS Warrington, KB Glaser, L Tian, M Lee, N Fujimoto, N Sathyamoorthy, PA Horwitz, R Januchowski, S McHugh, SD Zhang, Shu-Dong Zhang, ST Matalon, Timothy W Gant, VW Armstrong, Y Chen   +20 more
core   +5 more sources

A Novel Seven Gene Signature-Based Prognostic Model to Predict Distant Metastasis of Lymph Node-Negative Triple-Negative Breast Cancer

Frontiers in Oncology, 2021
BackgroundThe prognosis of lymph node-negative triple-negative breast cancer (TNBC) is still worse than that of other subtypes despite adjuvant chemotherapy.
Wenting Peng, Wenting Peng, Wenting Peng, Wenting Peng, Caijin Lin, Caijin Lin, Caijin Lin, Shanshan Jing, Shanshan Jing, Guanhua Su, Guanhua Su, Guanhua Su, Xi Jin, Xi Jin, Xi Jin, Genhong Di, Genhong Di, Genhong Di, Zhiming Shao, Zhiming Shao, Zhiming Shao   +20 more
doaj   +1 more source

A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity [PDF]

, 2014
Introduction: There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with human epidermal ...
Akbari, Mohammad R, Aldape, Kenneth D, Denton-Schneider, Benjamin R, Hicks, Daniel, Lee, Jeongeun, McMullin, Ryan P, Moulis, Sharon, Narod, Steven A, Ramaswamy, Sridhar, Sgroi, Dennis C, Singavarapu, Raj, Steeg, Patricia S, Wittner, Ben S, Yang, Chuanwei   +13 more
core   +1 more source

Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data. [PDF]

, 2014
Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year.
Bainbridge, Matthew N, Brown, Powel H, Haricharan, Svasti, Scheet, Paul   +3 more
core   +1 more source

A glycolysis-based 4-mRNA signature correlates with the prognosis and cell cycle process in patients with bladder cancer

Cancer Cell International, 2020
Background Bladder cancer is one of the most prevalent malignancies worldwide. However, traditional indicators have limited predictive effects on the clinical outcomes of bladder cancer.
Chen Zhang, Xin Gou, Weiyang He, Huaan Yang, Hubin Yin   +4 more
doaj   +1 more source

An immune cell activation signature reflected hepatocellular carcinoma heterogeneity and predicted clinical outcomes

Frontiers in Immunology
BackgroundThe prognosis of hepatocellular carcinoma (HCC) remains challenging, and immune activation plays a critical role in cancer treatment. Identifying reliable immune activation-related prognostic markers is critical for predicting HCC patient ...
Xiaofeng Wang, Dongli Liu, Shuai Wang, Rui He   +3 more
doaj   +1 more source