Results 31 to 40 of about 631,661 (355)

Gene signatures in hepatocellular carcinoma (HCC) [PDF]

Seminars in Cancer Biology, 2011
Primary hepatocellular carcinoma (HCC) is a significant human cancer globally, with poor prognosis. New and efficacious therapy strategies are needed as well as new biomarkers for early detection of at-risk patients. In this review, we discuss select microarray studies of human HCCs, and propose a gene signature that has promise for clinical ...
Andrisani, Ourania M, Studach, Leo, Merle, Philippe   +2 more
openaire   +4 more sources

An Immune-Gene-Based Classifier Predicts Prognosis in Patients With Cervical Squamous Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
Objective: Immunity plays a vital role in the human papilloma virus (HPV) persistent infection, and closely associates with occurrence and development of cervical squamous cell carcinoma (CSCC).
Huixia Yang, Xiaoyan Han, Zengping Hao
doaj   +1 more source

Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus

BMC Medical Genomics, 2019
Background We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. Methods Two hundred forty-three patients with
Michelle Petri, Wei Fu, Ann Ranger, Norm Allaire, Patrick Cullen, Laurence S. Magder, Yuji Zhang   +6 more
doaj   +1 more source

Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]

, 2019
Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina, Horák, Pavel, Kriegová, Eva, Kudělka, Miloš, Mrázek, František, Petráčková, Anna, Radvanský, Martin, Skácelová, Martina, Smržová, Andrea   +8 more
core   +1 more source

Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
doaj   +1 more source

NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. [PDF]

, 2019
The MYC oncogene is dysregulated in approximately 30% of liver cancer. In an effort to exploit MYC as a therapeutic target, including in hepatocellular carcinoma (HCC), strategies have been developed on the basis of MYC amplification or gene ...
Bodzin, Adam S., Budhu, Anuradha, Dang, Hien, Dominguez, Dana A., Lee, Ju-Seog, Martin, Sean P., Pomyen, Yotsawat, Shah, Ashesh P., Wang, Xin Wei, Yim, Sun Young   +9 more
core   +3 more sources

A Proposal for Gene Signature Integration

2009 9th International Conference on Information Technology and Applications in Biomedicine, 2009
Gene expression patterns that can distinguish to a clinically significant degree disease subclasses not only play a prominent role in diagnosis but also lead to therapeutic strategies that tailor treatment to the particular biology of each disease. Nevertheless, gene expression signatures derived through statistical feature identification procedures on
Ζερβακης Μιχαλης(http://users.isc.tuc.gr/~mzervakis), Zervakis Michalis(http://users.isc.tuc.gr/~mzervakis), Dimitrios Kafetzopoulos(), Michalis E. Blazadonakis()   +3 more
openaire   +3 more sources

Development and Validation of an E2F-Related Gene Signature to Predict Prognosis of Patients With Lung Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundLung squamous cell carcinoma (LUSC) generally correlates with poor clinical prognoses due to the lack of available prognostic biomarkers. This study is designed to identify a potential biomarker significant for the prognosis and treatment of ...
Cailian Wang, Xuyu Gu, Xiuxiu Zhang, Min Zhou, Yan Chen   +4 more
doaj   +1 more source

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. [PDF]

, 2014
With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardiac disease therapies.
Benner, Christopher, Crespo, Isaac, Del Sol, Antonio, Esteban, Concepcion Rodriguez, Gu, Ying, Izpisua Belmonte, Juan Carlos, Li, Mo, Liu, Guang-Hui, Montserrat, Nuria, Plongthongkum, Nongluk, Qu, Jing, Suzuki, Keiichiro, Yang, Jiping, Yi, Fei, Zhang, Kun, Zhang, Weiqi   +15 more
core   +3 more sources

Identification and Validation of an 11-Ferroptosis Related Gene Signature and Its Correlation With Immune Checkpoint Molecules in Glioma

Frontiers in Cell and Developmental Biology, 2021
BackgroundGlioma is the most common primary malignant brain tumor with significant mortality and morbidity. Ferroptosis, a novel form of programmed cell death (PCD), is critically involved in tumorigenesis, progression and metastatic processes.MethodsWe ...
Zhuohui Chen, Tong Wu, Zhouyi Yan, Mengqi Zhang   +3 more
doaj   +1 more source