Results 41 to 50 of about 631,661 (355)
Signature of arylacetamide deacetylase expression is associated with prognosis and immune infiltration in ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2022 Objective The role of the protein-coding gene arylacetamide deacetylase (AADAC) in the prognostication of ovarian cancer remains uncertain. We aimed to identify and validate its prognostic value using integrated bioinformatics analyses.
Jianyang Feng, Hong He
doaj +1 more source
BMC Bioinformatics, 2020 Background Despite the significant contribution of transcriptomics to the fields of biological and biomedical research, interpreting long lists of significantly differentially expressed genes remains a challenging step in the analysis process.
Bin Liu +5 more
doaj +1 more source
Frontiers in Genetics, 2023 Objective: Epithelial-mesenchymal transition (EMT) is linked to an unfavorable prognosis in oral squamous cell carcinoma (OSCC). Here, we aimed to develop an EMT gene signature for OSCC prognosis.Methods: In TCGA dataset, prognosis-related EMT genes with
Jun Ai +6 more
doaj +1 more source
Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data. [PDF]
, 2014 Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year.
Bainbridge, Matthew N +3 more
core +1 more source
Frontiers in Oncology, 2021 BackgroundThe prognosis of lymph node-negative triple-negative breast cancer (TNBC) is still worse than that of other subtypes despite adjuvant chemotherapy.
Wenting Peng +20 more
doaj +1 more source
Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis. [PDF]
, 2013 BackgroundBrucellosis, a zoonotic infection caused by one of the Gram-negative intracellular bacteria of the Brucella genus, is an ongoing public health problem in Perú.
Feldman, Kristyn E +9 more
core +3 more sources
Gene Signatures in CRC and Liver Metastasis [PDF]
, 2011 Colorectal cancer (CRC) is one of the most common causes of cancer-related death with a worldwide incidence of almost a million cases annually in both males and females. The accelerated decrease in CRC incidence rates from 1998 to 2006 largely reflects the advances in diagnosis and treatment that have enabled to detect and remove precancerous polyps ...
Fanale, Daniele +3 more
openaire +3 more sources
Genomic signatures of germline gene expression [PDF]
Genome Research, 2010 Transcribed regions in the human genome differ from adjacent intergenic regions in transposable element density, crossover rates, and asymmetric substitution and sequence composition patterns. We tested whether these differences reflect selection or are instead a byproduct of germline transcription, using publicly available gene expression data from a ...
Graham McVicker, Philip Green
openaire +3 more sources
Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes [PDF]
, 2012 Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Ana B. Martínez-Cruz +16 more
core +12 more sources
Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression [PDF]
, 2018 PurposeGene expression profiling can uncover biologic mechanisms underlying disease and is important in drug development. RNA sequencing (RNA-seq) is routinely used to assess gene expression, but costs remain high.
Dunne, Philip +15 more
core +4 more sources