Results 61 to 70 of about 3,125,604 (306)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Development and validation of a prognostic gene-expression signature for lung adenocarcinoma. [PDF]

PLoS ONE, 2012
Although several prognostic signatures have been developed in lung cancer, their application in clinical practice has been limited because they have not been validated in multiple independent data sets.
Yun-Yong Park, Eun Sung Park, Sang Bae Kim, Sang Cheol Kim, Bo Hwa Sohn, In-Sun Chu, Woojin Jeong, Gordon B Mills, Lauren Averett Byers, Ju-Seog Lee   +9 more
doaj   +1 more source

Slug-based epithelial-mesenchymal transition gene signature is associated with prolonged time to recurrence in glioblastoma [PDF]

, 2011
Background We previously identified a precise stage-associated gene expression signature of coordinately expressed genes, including the transcription factor Slug (SNAI2) and other epithelial mesenchymal transition (EMT) markers, present in ...
Jessica J. Kandel, Peter Canoll, Darrell J. Yamashiro, Wei-Yi Cheng, Dimitris Anastassiou   +4 more
core  

Prognostic gene expression signature for high-grade serous ovarian cancer [PDF]

, 2020
Background: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis.
Millstein, J., Elatre, W, Volchek, M, Gilks, B., Brown, B., Nazeran, T., Volchek, M., Chen, S, Anglesio, MS, Millstein, J, Hung, J, Links, M., Anglesio, M. S., Goode, E. L., Nazeran, T, Intermaggio, MP, Leong, HS, Elatre, W., Budden, T, Talhouk, A, Bentley, RC, Hill, J., Chen, S., Intermaggio, M. P., Talhouk, A., Gilks, B, Goode, EL, Leong, H. S., Budden, T., et al.   +29 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Expression of Alpha-type Platelet-derived Growth Factor Receptor–influenced Genes Predicts Clinical Outcome in Glioma

Translational Oncology, 2020
BACKGROUND: Alpha-type platelet-derived growth factor receptor (PDGFRα) is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
Eun-A Ko, Haeyeong Lee, Kenton M. Sanders, Sang Don Koh, Tong Zhou   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A novel gene signature based on five immune checkpoint genes predicts the survival of glioma

Chinese Neurosurgical Journal, 2021
Background Glioma is the most common and fatal type of nerve neoplasm in the central nervous system. Several biomarkers have been considered for prognosis prediction, which is not accurate enough.
Wei Zhang, You Zhai, Guanzhang Li, Tao Jiang   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source